4-(TRIFLUOROMETHYLSULFONYL)ANILINE

Base Information

• Chemical Name: 4-(TRIFLUOROMETHYLSULFONYL)ANILINE
• CAS No.: 473-27-8
• Molecular Formula: C7H6F3NO2S
• Molecular Weight: 225.191
• Hs Code.: 2921420090
• Mol file: 473-27-8.mol

Synonyms:Aniline,p-[(trifluoromethyl)sulfonyl]- (6CI,7CI,8CI);4-(Trifluoromethanesulfonyl)aniline;4-(Trifluoromethylsulfonyl)aniline;4-Aminophenyl trifluoromethyl sulfone;4-Trifluoromethylsulfonylphenylamine;p-[(Trifluoromethyl)sulfonyl]aniline;

Chemical Property of 4-(TRIFLUOROMETHYLSULFONYL)ANILINE

Chemical Property:

• Vapor Pressure: 0.000376mmHg at 25°C
• Melting Point: 96 °C(lit.)
• Refractive Index: 1.501
• Boiling Point: 317.8 °C at 760 mmHg
• PKA: -0.01±0.10(Predicted)
• Flash Point: 146 °C
• PSA: 68.54000
• Density: 1.502 g/cm³
• LogP: 3.22430
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Trifluoromethylsulfonyl)benzenamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T
• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-(Trifluoromethylsulfonyl)aniline may be used in the preparation of 1-azido-4(trifluoromethanesufonyl)benzene.

Technology Process of 4-(TRIFLUOROMETHYLSULFONYL)ANILINE

There total 1 articles about 4-(TRIFLUOROMETHYLSULFONYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-nitro-4-(trifluoromethylsulfonyl)benzene (432-87-1) → 4-(trifluoromethanesulfonyl)aniline (473-27-8)

Guidance literature:

With hydrogenchloride; tin(ll) chloride;

DOI:10.1080/00304940309355835

Reference yield: 84.0%

4-(trifluoromethanesulfonyl)aniline (473-27-8) → 4-((trifluoromethyl)sulfonyl)benzene-1-sulfonyl chloride (63647-64-3)

Guidance literature:

4-(trifluoromethanesulfonyl)aniline; With hydrogenchloride; In water;

With sodium nitrite; In water; for 0.25h;

With sulfur dioxide; copper(l) chloride; In water; at 0 ℃; for 0.5h;

Reference yield: 82.0%

4-(trifluoromethanesulfonyl)aniline (473-27-8) → 1-azido-4-(trifluoromethanesulfonyl)benzene (31641-76-6)

Guidance literature:

4-(trifluoromethanesulfonyl)aniline; With hydrogenchloride; urea; sodium nitrite; at 0 ℃; for 1h;

With sodium azide; potassium acetate; In water; at 0 ℃; for 2h; Further stages.;

DOI:10.1021/ac800855u

upstream raw materials:

1-nitro-4-(trifluoromethylsulfonyl)benzene

Downstream raw materials:

Trifluormethyl-<2-amino-benzthiazol-(6)-yl>-sulfon

1-bromo-4-(trifluoromethylsulfonyl)benzene

1-iodo-4-((trifluoromethyl)sulfonyl)benzene

C,C,C-Trifluoro-N-(4-trifluoromethanesulfonyl-phenyl)-methanesulfonamide