3,4-Dimethoxynitrobenzene

Base Information

• Chemical Name: 3,4-Dimethoxynitrobenzene
• CAS No.: 709-09-1
• Molecular Formula: C8H9NO4
• Molecular Weight: 183.164
• Hs Code.: 29093090
• European Community (EC) Number: 211-906-2
• NSC Number: 93382,27974,10116
• DSSTox Substance ID: DTXSID9061043
• Nikkaji Number: J150.894F
• Wikidata: Q63396182
• Mol file: 709-09-1.mol

Synonyms:3,4-Dimethoxynitrobenzene;709-09-1;1,2-Dimethoxy-4-nitrobenzene;4-Nitroveratrole;Benzene, 1,2-dimethoxy-4-nitro-;4-Nitrcveratrole;NSC 27974;3,4-Dimethoxy-1-nitrobenzene;EINECS 211-906-2;NSC 10116;NSC 93382;AI3-20861;Benzene,2-dimethoxy-4-nitro-;3,4-dimethoxylnitrobenzene;4-nitroveratrol;4-Nitro-veratrole;MFCD00007238;4-NITRO-1,2-DIMETHOXYBENZENE;3,4-dimethoxy nitrobenzene;3,4-dimethoxy- nitrobenzene;ghl.PD_Mitscher_leg0.858;SCHEMBL527567;DTXSID9061043;AMY2531;NSC10116;NSC27974;NSC93382;NSC-10116;NSC-27974;NSC-93382;STL388031;AKOS000120729;2-Methoxy-5-nitrophenol, methyl ether;AS-58398;A9319;CS-0127987;D1488;FT-0619307;EN300-18217;D71262;W-104540;Q63396182

Chemical Property of 3,4-Dimethoxynitrobenzene

Chemical Property:

• Appearance/Colour: yellow crystals or crystalline powder
• Vapor Pressure: 1.16E-05mmHg at 25°C
• Melting Point: 95-98 °C(lit.)
• Refractive Index: 1.645
• Boiling Point: 376.9 °C at 760 mmHg
• Flash Point: 145.9 °C
• PSA: 64.28000
• Density: 1.226 g/cm³
• LogP: 2.13520
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 183.05315777
• Heavy Atom Count: 13
• Complexity: 180

Purity/Quality:

99% ^*data from raw suppliers

4-Nitro-veratrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 36-26

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Nitros, Aromatic
• Canonical SMILES: COC1=C(C=C(C=C1)[N+](=O)[O-])OC
• Uses: 4-Nitro-veratrole (cas# 709-09-1) is a compound useful in organic synthesis.

Technology Process of 3,4-Dimethoxynitrobenzene

There total 58 articles about 3,4-Dimethoxynitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2-dimethoxybenzene (91-16-7) → 3,4-dimethoxynitrobenzene (709-09-1)

Guidance literature:

With Nitrogen dioxide; In dichloromethane; in the dark; -78 deg C, 2 min; RT, 15 min;

DOI:10.1016/S0040-4020(01)81329-6

Reference yield: 100.0%

4,5-dimethoxy-2-nitro-benzoic acid (4998-07-6) → 3,4-dimethoxynitrobenzene (709-09-1)

Guidance literature:

With silver carbonate; In dimethyl sulfoxide; at 120 ℃; for 16h;

DOI:10.1039/b916646g

Reference yield: 92.0%

3,4-Dimethoxyphenylboronic acid (122775-35-3) → 3,4-dimethoxynitrobenzene (709-09-1)

Guidance literature:

With N-Bromosuccinimide; [bis(trifluoroacetoxy)iodo]benzene; sodium nitrite; In acetonitrile; at 20 ℃; for 3h; regioselective reaction;

DOI:10.1039/c5ob00337g

upstream raw materials:

diazomethane

1,2-dihydroxy-4-nitrobenzene

methanol

1-ethoxy-2-methoxy-4-nitrobenzene

Downstream raw materials:

N-(4,5-dimethoxy-2-nitro-benzyl)-succinimide

4,5-dimethoxy-2-nitrobenzyl phthalimide

N-(4,5-dimethoxy-2-nitro-benzyl)-benzamide

bis-(3,4-dimethoxy-phenyl)-diazene

Refernces

• 1、 Blum, Stephan P.,Nickel, Christean,Sch?ffer, Lukas,Karakaya, Tarik,Waldvogel, Siegfried R.. "Electrochemical Nitration with Nitrite". . p. 4936 - 4940. Retrieved 2021/10/25.
• 2、 Altmann, Lisa-Marie,Heinrich, Markus R.,Hofmann, Dagmar,Hofmann, Laura Elena,Prusko, Lea. "Sequential Cleavage of Lignin Systems by Nitrogen Monoxide and Hydrazine". . . Retrieved 2020/03/27.