(4-chlorophenyl) propanoate

Base Information

• Chemical Name: (4-chlorophenyl) propanoate
• CAS No.: 61469-49-6
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Hs Code.: 2915509000
• Mol file: 61469-49-6.mol

Synonyms:Propionicacid, p-chlorophenyl ester (7CI);4-Chlorophenyl propionate;NSC 52967;p-Chlorophenyl propionate;

Chemical Property of (4-chlorophenyl) propanoate

Chemical Property:

• Vapor Pressure: 0.0229mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 249.4 °C at 760 mmHg
• Flash Point: 115.4 °C
• PSA: 26.30000
• Density: 1.187 g/cm³
• LogP: 2.65540

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-chlorophenyl) propanoate

There total 3 articles about (4-chlorophenyl) propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

propionyl chloride (79-03-8) + 4-chloro-phenol (106-48-9,82344-39-6) → 4-chlorophenyl propionate (61469-49-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jo060002n

Reference yield: 70.0%

propionic acid (802294-64-0,79-09-4) + 4-chloro-phenol (106-48-9,82344-39-6) → 4-chlorophenyl propionate (61469-49-6)

Guidance literature:

propionic acid; With thionyl chloride; for 0.5h; Reflux;

4-chloro-phenol; With triethylamine; In dichloromethane; for 1h; Reflux;

DOI:10.1002/bkcs.10067

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) + propionic acid anhydride (123-62-6) → 4-chlorophenyl propionate (61469-49-6)

Guidance literature:

With pyridine; In diethyl ether; Heating;

upstream raw materials:

propionyl chloride

4-chloro-phenol

propionic acid anhydride

propionic acid

Downstream raw materials:

3-bromo-5-chloro-2-hydroxypropiophenone

Refernces

• 1、 Youssif, Bahaa G.M.,Mohamed, Ashraf M.,Osman, Essam Eldin A.,Abou-Ghadir, Ola F.,Elnaggar, Dina H.,Abdelrahman, Mostafa H.,Treamblu, Laurent,Gomaa, Hesham A.M.. "5-Chlorobenzofuran-2-carboxamides: From allosteric CB1 modulators to potential apoptotic antitumor agents". . p. 1 - 11. Retrieved 2019/05/27.
• 2、 Fransson, Ann-Britt L.,Xu, Yongmei,Leijondahl, Karin,Baeckvall, Jan-E.. "Enzymatic resolution, desymmetrization, and dynamic kinetic asymmetric transformation of 1,3-cycloalkanediols". . p. 6309 - 6316. Retrieved 2007/10/03.