4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE

Base Information

• Chemical Name: 4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE
• CAS No.: 2836-44-4
• Molecular Formula: C6H5F3N2O
• Molecular Weight: 178.11
• Hs Code.: 29335990
• Mol file: 2836-44-4.mol

Synonyms:4(1H)-Pyrimidinone,2-methyl-6-(trifluoromethyl)- (9CI);4-Pyrimidinol,2-methyl-6-(trifluoromethyl)- (6CI,7CI,8CI);4-Hydroxy-2-methyl-6-trifluoromethylpyrimidine;NSC 33044;6-Hydroxy-2-methyl-4-trifluoromethylpyrimidine;2-Methyl-6-(trifluoromethyl)-4-pyrimidinol;4-Pyrimidinol, 2-methyl-6- (trifluoromethyl)-;

Chemical Property of 4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE

Chemical Property:

• Vapor Pressure: 6.886mmHg at 25°C
• Melting Point: 141.0 to 145.0 °C
• Refractive Index: 1.427
• Boiling Point: 148.6 °C at 760 mmHg
• PKA: 6.83±0.50(Predicted)
• Flash Point: 43.7 °C
• PSA: 46.01000
• Density: 1.47 g/cm³
• LogP: 1.50940
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-6-(trifluoromethyl)pyrimidin-4-ol ^*data from reagent suppliers

Safty Information:

• Statements: 20/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE

There total 3 articles about 4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

ethanimidamide hydrochloride + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 2-methyl-6-(trifluoromethyl)pyrimidin-4-ol (2836-44-4)

Guidance literature:

ethyl 4,4,4-trifluoroacetoacetate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; for 1h;

ethanimidamide hydrochloride; In ethanol; Reflux;

Reference yield: 85.7%

acetamidine hydrochloride (124-42-5) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 2-methyl-6-(trifluoromethyl)pyrimidin-4-ol (2836-44-4)

Guidance literature:

acetamidine hydrochloride; ethyl 4,4,4-trifluoroacetoacetate; With sodium methylate; In ethanol; for 10h; Reflux;

With hydrogenchloride; In ethanol; pH=7;

DOI:10.1007/s11696-018-0583-7

Reference yield:

acetamidine hydrochloride (124-42-5) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 2-methyl-4-(trifluoromethyl)-1H-pyrimidin-6-one (2836-44-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1111/j.1945-5100.2000.tb01518.x

upstream raw materials:

acetamidine hydrochloride

ethyl 4,4,4-trifluoroacetoacetate

Downstream raw materials:

4-chloro-2-methyl-6-(trifluoromethyl)pyrimidine

Refernces

• 1、 Yu, Xuetong,Lan, Wenjun,Chen, Meihang,Xu, Su,Luo, Xiaoxi,He, Shuhong,Chen, Haijiang,Fei, Qiang,Wu, Wenneng. "Synthesis and Antifungal and Insecticidal Activities of Novel N -Phenylbenzamide Derivatives Bearing a Trifluoromethylpyrimidine Moiety". . . Retrieved 2021/10/07.
• 2、 -. "PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL". Page/Page column 175; 176. . Retrieved 2010/12/18.