Z-LEU-OH DCHA

Base Information

• Chemical Name: Z-LEU-OH DCHA
• CAS No.: 53363-87-4
• Molecular Formula: C26H42N2O4
• Molecular Weight: 446.63
• Hs Code.: 29225090
• Mol file: 53363-87-4.mol

Synonyms:L-Leucine, N-((phenylmethoxy)carbonyl)-, compd. with N-cyclohexylcyclohexanamine (1:1);Z-Leu-OH·DCHA;Z-L-Leucine dicyclohexylamine salt;Z-Leu-OH?DCHA;Z-Leu-OH.DCHA;Z-L-Leucine.DCHA;N-cyclohexylcyclohexanamine; 4-methyl-2-phenylmethoxycarbonylamino-pentanoic acid;

Chemical Property of Z-LEU-OH DCHA

Chemical Property:

• Vapor Pressure: 1.28E-08mmHg at 25°C
• Boiling Point: 612.2 °C at 760 mmHg
• Flash Point: 324 °C
• PSA: 87.66000
• LogP: 6.43530
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98% ^*data from raw suppliers

Z-L-leucine dicyclohexylammonium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-LEU-OH DCHA

There total 2 articles about Z-LEU-OH DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + N-cyclohexyl-cyclohexanamine (101-83-7) + dimethylsulfonium methyl sulfate → N-(benzyloxycarbonyl)leucine dicyclohexylamine salt (53363-87-4)

Guidance literature:

With triethylamine; In water; Ambient temperature;

DOI:10.1246/bcsj.62.3103

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + benzyl chloroformate (501-53-1,94274-21-2) + N-cyclohexyl-cyclohexanamine (101-83-7) → N-(benzyloxycarbonyl)leucine dicyclohexylamine salt (53363-87-4)

Guidance literature:

With sodium hydroxide; Multistep reaction; 1.) ca 5 deg C, 15 min 2.) ethyl acetate, Et₂O, 5 min;

DOI:10.1016/S0040-4020(01)87839-X

Reference yield:

N-(benzyloxycarbonyl)leucine dicyclohexylamine salt (53363-87-4) → Z-Leu-OH (2018-66-8)

Guidance literature:

With sulfuric acid; In water; ethyl acetate; Cooling with ice;

DOI:10.1002/anie.200705858

upstream raw materials:

L-leucine

benzyl chloroformate

N-cyclohexyl-cyclohexanamine

Downstream raw materials:

Z-Leu-Anthranilsaeureethylester

[2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-benzoylamino]-acetic acid ethyl ester

methyl N-benzyloxycarbonyl-L-leucylglicynate

N-benzyloxycarbonyl-L-leucyl-L-alanine methyl ester

Refernces

• 1、 Azuse,Tamura,Kinomura,Okai,Kouge,Hamatsu,Koizumi. "Peptide synthesis in aqueous solution. IV. Preparation and properties of [p-(benzyloxycarbonyloxy)phenyl]dimethylsulfonium methyl sulfate, [p-(t-butoxycarbonyloxy)phenyl]dimethylsulfonium methyl sulfate and [p-(9-fluorenylmethyl-oxycarbonyloxy)phenyl]dimethylsulfonium methyl sulfate as water-soluble N-acylating reagents". . p. 3103 - 3108. Retrieved 2007/10/02.