Rheic Acid;Rhubarb yellow;Monorhein

Base Information

• Chemical Name: Rheic Acid;Rhubarb yellow;Monorhein
• CAS No.: 76-66-4
• Molecular Formula: C₂₂H₂₈N₂O₄
• Molecular Weight: 384.475
• Hs Code.: 29399990
• European Community (EC) Number: 683-092-0
• ChEMBL ID: CHEMBL1668786
• Metabolomics Workbench ID: 70231
• Nikkaji Number: J9.110C
• Wikipedia: Rhynchophylline
• Mol file: 76-66-4.mol

Synonyms:isorhynchophylline;isorhyncophylline;rhynchophylline;rhyncophylline;rhyncophylline, (16E)-isomer;rhyncophylline, (16E,20alpha)-isomer

Chemical Property of Rheic Acid;Rhubarb yellow;Monorhein

Chemical Property:

• Appearance/Colour: Red brown or white fine powder
• Vapor Pressure: 1.32E-12mmHg at 25°C
• Melting Point: 216°; mp 197-199° (Ban et al., loc. cit.)
• Refractive Index: 1.596
• Boiling Point: 560.8 °C at 760 mmHg
• PKA: 6.4(at 25℃)
• Flash Point: 293 °C
• PSA: 67.87000
• Density: 1.23 g/cm³
• LogP: 2.77610
• Storage Temp.: 0-10°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 384.20490738
• Heavy Atom Count: 28
• Complexity: 663

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Rhynchophylline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O
• Isomeric SMILES: CC[C@H]1CN2CC[C@]3([C@@H]2C[C@@H]1/C(=C/OC)/C(=O)OC)C4=CC=CC=C4NC3=O
• Uses: Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor.

Technology Process of Rheic Acid;Rhubarb yellow;Monorhein

There total 16 articles about Rheic Acid;Rhubarb yellow;Monorhein which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(±)-corynoxeine (630-94-4,51014-29-0) → rhynchophylline (76-66-4,6859-01-4,6877-32-3,17391-18-3,39032-61-6,39032-62-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 18h; under 760.051 Torr;

DOI:10.1002/ejoc.201201505

Reference yield:

C25H29N3O8S → rhynchophylline (76-66-4,6859-01-4,6877-32-3,17391-18-3,39032-61-6,39032-62-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: thiophenol; potassium carbonate / dimethyl sulfoxide / 2.15 h

2.1: triethylamine / acetonitrile / 2.33 h / 20 °C

3.1: caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 8 h / Inert atmosphere

4.1: 6 h / 0 °C

5.1: tetrahydrofuran / 0.08 h / 20 °C

5.2: -78 - 20 °C

5.3: 20 h / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h / 760.05 Torr

With bis(η3-allyl-μ-chloropalladium(II)); palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; acetonitrile; 5.2: |Wittig Olefination;

DOI:10.1002/ejoc.201201505

Reference yield:

C19H26N2O4 (1443767-64-3) → rhynchophylline (76-66-4,6859-01-4,6877-32-3,17391-18-3,39032-61-6,39032-62-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / acetonitrile / 2.33 h / 20 °C

2.1: caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 8 h / Inert atmosphere

3.1: 6 h / 0 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

4.2: -78 - 20 °C

4.3: 20 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h / 760.05 Torr

With bis(η3-allyl-μ-chloropalladium(II)); palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; ethyl acetate; acetonitrile; 4.2: |Wittig Olefination;

DOI:10.1002/ejoc.201201505

upstream raw materials:

C₁₉H₂₆N₂O₄

tert-butyl 2-oxohex-5-enoate

tryptamine

tert-butyl 2,5-dioxopentanoate

Refernces

• 1、 -. "Process for the production of specific isomer mixtures from oxindole alkaloids". . . Retrieved 2008/06/13.