PHLOROGLUCINOL TRIACETATE

Base Information

• Chemical Name: PHLOROGLUCINOL TRIACETATE
• CAS No.: 2999-40-8
• Molecular Formula: C12H12O6
• Molecular Weight: 252.224
• Mol file: 2999-40-8.mol

Synonyms:1,3,5-Benzenetriol,triacetate (9CI);Phloroglucinol, triacetate (6CI,7CI);1,3,5-Triacetoxybenzene;1,3,5-Tris(acetyloxy)benzene;NSC 16958;Phloroglucinol triacetate;Benzene-1,3,5-triyl triacetate;(3,5-Diacetyloxyphenyl) ethanoate;Acetic acid (3,5-diacetoxyphenyl) ester;

Chemical Property of PHLOROGLUCINOL TRIACETATE

Chemical Property:

• Melting Point: 104-105 ºC
• Boiling Point: 348.7 ºC at 760 mmHg
• Flash Point: 153.4 ºC
• PSA: 78.90000
• Density: 1.246 g/cm³
• LogP: 1.46250

Purity/Quality:

98%min ^*data from raw suppliers

PholoroglucinolTriacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PHLOROGLUCINOL TRIACETATE

There total 13 articles about PHLOROGLUCINOL TRIACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,5-dihydroxyphenol (108-73-6) + acetic anhydride (108-24-7) → 1,3,5-triacetoxybenzene (2999-40-8)

Guidance literature:

With pyridine;

DOI:10.1002/ardp.201200125

Reference yield: 97.0%

Isopropenyl acetate (108-22-5) + 3,5-dihydroxyphenol (108-73-6) → 1,3,5-triacetoxybenzene (2999-40-8)

Guidance literature:

With iodine; at 85 - 90 ℃; for 0.75h;

DOI:10.1016/j.tetlet.2006.05.122

Reference yield: 79.0%

1,2,3-trimethoxybenzene (621-23-8) + acetic acid (64-19-7,77671-22-8) → 1,3,5-triacetoxybenzene (2999-40-8)

Guidance literature:

1,2,3-trimethoxybenzene; With boron tribromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

acetic acid; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.3184/174751912X13324176277811

upstream raw materials:

Ketene

3,5-dihydroxyphenol

sodium acetate

acetic anhydride

Refernces

• 1、 Dao, Viet Hung,Ourliac-Garnier, Isabelle,Bazin, Marc-Antoine,Jacquot, Catherine,Baratte, Blandine,Ruchaud, Sandrine,Bach, Stéphane,Grovel, Olivier,Le Pape, Patrice,Marchand, Pascal. "Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration". . p. 2250 - 2255. Retrieved 2018/05/30.
• 2、 Hintz, Heather A.,Sortedahl, Nicholas J.,Meyer, Samantha M.,Decato, Daniel A.,Dahl, Bart J.. "The synthesis of lactone-bridged 1,3,5-triphenylbenzene derivatives as pi-expanded coumarin triskelions". supporting information. p. 4703 - 4708. Retrieved 2017/11/17.