2-FLUORO-2-DEOXY-D-GALACTOPYRANOSE

Base Information

• Chemical Name: 2-FLUORO-2-DEOXY-D-GALACTOPYRANOSE
• CAS No.: 51146-53-3
• Molecular Formula: C₆H₁₁FO₅
• Molecular Weight: 182.149
• Hs Code.: 2913000090
• Mol file: 51146-53-3.mol

Synonyms:2-Deoxy-2-fluoro-D-galactose;

Chemical Property of 2-FLUORO-2-DEOXY-D-GALACTOPYRANOSE

Chemical Property:

• Vapor Pressure: 1.44E-08mmHg at 25°C
• Melting Point: 131-135 °C
• Refractive Index: 1.535
• Boiling Point: 478.4 °C at 760 mmHg
• Flash Point: 243.1 °C
• PSA: 90.15000
• Density: 1.494 g/cm³
• LogP: -2.24420
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Purity/Quality:

99%, ^*data from raw suppliers

2-Deoxy-2-fluoro-D-galactose ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Deoxy-2-fluoro-D-galactose (cas# 51146-53-3) is a compound useful in organic synthesis.

Technology Process of 2-FLUORO-2-DEOXY-D-GALACTOPYRANOSE

There total 3 articles about 2-FLUORO-2-DEOXY-D-GALACTOPYRANOSE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,4,6-tetra-O-acetyl-2-deoxy-2-fluoro-α/β-D-glucopyranoside (141395-48-4) → 2-fluoro-2-deoxy-D-glucose (38440-79-8,51146-53-3,63639-24-7,90135-70-9,136529-55-0,136596-31-1,29702-43-0)

Guidance literature:

With sodium methylate; In methanol; for 0.116667h; Ambient temperature; var.: 1M HCl, reflux, 40 min;

DOI:10.1016/S0008-6215(00)90137-X

Reference yield:

Fluoro-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-acetaldehyde (84780-21-2,109680-89-9) → (3S,4R,5R)-2-Fluoro-3,4,5,6-tetrahydroxy-hexanal (29702-43-0,38440-79-8,51146-53-3,63639-24-7,90135-70-9,136529-55-0,136596-31-1)

Guidance literature:

With trifluoroacetic acid; for 0.0833333h; Ambient temperature;

DOI:10.1016/S0008-6215(00)90137-X

Reference yield:

→ 2-fluoro-2-deoxy-D-glucose (38440-79-8,51146-53-3,63639-24-7,90135-70-9,136529-55-0,136596-31-1,29702-43-0)

Guidance literature:

upstream raw materials:

Fluoro-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-acetaldehyde

1,3,4,6-tetra-O-acetyl-2-deoxy-2-fluoro-α/β-D-glucopyranoside

Downstream raw materials:

1,3,4,6-tetra-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranose

1,3,4,6-tetra-O-acetyl-2-deoxy-2-fluoro-α-D-glucopyranose

[(2R,3R,4S,5S)-3,4,6-triacetoxy-5-fluoro-tetrahydropyran-2-yl]methyl acetate

Refernces

• 1、 Szarek, Walter A.,Hay, George W.,Doboszewski, Bogdan,Perlmutter, Milton M.. "REACTION OF 1,2-ANHYDRO-3,4:5,6-DI-O-ISOPROPYLIDENE-1-C-NITRO-D-MANNITOL WITH POTASSIUM HYDROGENEFLUORIDE IN ETHYLENE GLYCOL: A SYNTHESIS OF 2-DEOXY-2-FLUORO-D-GLUCOSE". . p. 107 - 118. Retrieved 2007/10/02.