Pyridine-2,6-dicarbonitrile

Base Information

• Chemical Name: Pyridine-2,6-dicarbonitrile
• CAS No.: 2893-33-6
• Molecular Formula: C7H3N3
• Molecular Weight: 129.121
• Hs Code.: 29333990
• European Community (EC) Number: 220-766-1
• DSSTox Substance ID: DTXSID50183130
• Nikkaji Number: J27.999D
• Wikidata: Q72503869
• ChEMBL ID: CHEMBL308846
• Mol file: 2893-33-6.mol

Synonyms:Pyridine-2,6-dicarbonitrile;2,6-Pyridinedicarbonitrile;2893-33-6;2,6-dicyanopyridine;CHEMBL308846;EINECS 220-766-1;MFCD00129021;2,6-DICYANO PYRIDINE;SCHEMBL995983;XNPMXMIWHVZGMJ-UHFFFAOYSA-;AMY3109;DTXSID50183130;2,6-Pyridinedicarbonitrile, 97%;Cl-1161;BCP29175;1,3-Adamantanedimethanol,alpha,alpha,alpha',alpha'-Tetramethyl-(6CI);BDBM50403308;STK279684;AKOS005426277;CS-W008958;MS-2145;SY034689;A5444;FT-0653340;EN300-37495;2,6-Dicyanopyridine;J-017329;Z381540986

Chemical Property of Pyridine-2,6-dicarbonitrile

Chemical Property:

• Vapor Pressure: 0.00213mmHg at 25°C
• Melting Point: 123-127 °C
• Refractive Index: 1.567
• Boiling Point: 289.983 °C at 760 mmHg
• PKA: -5.87±0.10(Predicted)
• Flash Point: 107.216 °C
• PSA: 60.47000
• Density: 1.254 g/cm³
• LogP: 0.82496
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 129.032697108
• Heavy Atom Count: 10
• Complexity: 181

Purity/Quality:

Pyridine-2,6-dicarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)C#N)C#N
• Uses: 2,6-Pyridinedicarbonitrile may be used to synthesize bis-tetrazoles and pyridine-based tridentate ligand 2,6-bis(α-aminoisopropyl)pyridine.

Technology Process of Pyridine-2,6-dicarbonitrile

There total 15 articles about Pyridine-2,6-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,6-Pyridinedicarboxaldehyde (5431-44-7) → pyridine-2,6-dinitrile (2893-33-6)

Guidance literature:

With ammonium acetate; phenyltrimethylammonium tribromide; In dichloromethane; at 20 ℃; for 16h;

DOI:10.3987/COM-16-13542

Reference yield: 90.0%

pyridine-2,6-dicarboxylic acid diamide (4663-97-2) → pyridine-2,6-dinitrile (2893-33-6)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1007/BF00505773

Reference yield: 90.0%

N'-[6-(dimethyl-hydrazonomethyl)-pyridin-2-ylmethylene]-N,N-dimethyl-hydrazine (100140-49-6) → pyridine-2,6-dinitrile (2893-33-6)

Guidance literature:

With potassium carbonate; dimethyl sulfate; In acetonitrile; for 16h; Heating;

DOI:10.1081/SCC-200032468

upstream raw materials:

pyridine-2,6-dicarboxylic acid diamide

2-cyanopyridine N-oxide

trimethylsilyl cyanide

N'-[6-(dimethyl-hydrazonomethyl)-pyridin-2-ylmethylene]-N,N-dimethyl-hydrazine

Downstream raw materials:

2,6-bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine

2,6-bis[(4R)-5,5-dihydro-4-phenyl-2-oxazolyl]pyridine

2,6-bis[4'-(S)-(tert-butyl)oxazolin-2'-yl]pyridine

pyridine-2,6-dicarbothioamide

Refernces

• 1、 Zhang, Yinsheng,Greenfield, Laura,Hong, Yang. "Syntheses of dual-radioisotope-labeled CP-I, a GABAA receptor partial agonist". . p. 411 - 417. Retrieved 2011.
• 2、 Hardy,Wyss,Eddy,Gorden. "An example of unusual pyridine donor Schiff base uranyl (UO22+) complexes". . p. 5718 - 5720. Retrieved 2017.
• 3、 Ansari, S. A.,Bhattacharyya, Arunasis,Karthikeyan, N. S.,Mohapatra, P. K.,Rao, T. S.,Ravichandran, C.,Seshadri, H.,Venkatachalapathy, B.. "Bis-(1,2,4-triazin-3-yl) ligand structure driven selectivity reversal between Am3+and Cm3+: solvent extraction and DFT studies". supporting information. p. 7783 - 7790. Retrieved 2021/06/16.
• 4、 Stemper, Jérémy,Tuo, Wei,Mazarío, Eva,Helal, Ahmed S.,Djurovic, Alexandre,Lion, Claude,El Hage Chahine, Jean-Michel,Maurel, Fran?ois,Hémadi, Miryana,Le Gall, Thierry. "Synthesis of bis(amidoxime)s and evaluation of their properties as uranyl-complexing agents". . p. 2641 - 2649. Retrieved 2018/04/20.