Incyclinide

Base Information

• Chemical Name: Incyclinide
• CAS No.: 15866-90-7
• Molecular Formula: C19H17 N O7
• Molecular Weight: 371.346
• Mol file: 15866-90-7.mol

Synonyms:2-Naphthacenecarboxamide,1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo- (7CI,8CI);2-Naphthacenecarboxamide,1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, [4aS-(4aa,5aa,12aa)]-;4-De(dimethylamino)-6-demethyl-6-deoxytetracycline;4-De(dimethylamino)sancycline;CMT 3;COL 3;Incyclinide;Metastat;NSC 683551;

Chemical Property of Incyclinide

Chemical Property:

• Melting Point: 228-231 °C
• Boiling Point: 752.8±60.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 158.15000
• Density: 1.70±0.1 g/cm3(Predicted)
• LogP: 1.28080

Purity/Quality:

99% ^*data from raw suppliers

COL3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Treatment of acne, rosacea, and acute respiratory distress syndrome. Incyclinide is MMP inhibitor. Potential anti-COVID-19 drugs which which significantly downregulate ACE2 activity.

Technology Process of Incyclinide

There total 1 articles about Incyclinide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-Desmethylamino-6-desmethyl-6-desoxy-tetracyclin (15866-90-7)

Guidance literature:

6-Desmethyl-6-desoxy-tetracyclin, 1. CH3I, Acn., Raumtemp., 72 h (-> 6-Desmethyl-6-desoxy-tetracyclin-methyliodid), 2. Zn-Staub, CH3COOH, 15 min;

DOI:10.1021/ja00900a027