2,2-bis(bromomethyl)-1,3-dioxolane

Base Information

• Chemical Name: 2,2-bis(bromomethyl)-1,3-dioxolane
• CAS No.: 20599-01-3
• Molecular Formula: C5H8Br2O2
• Molecular Weight: 259.925
• Mol file: 20599-01-3.mol

Synonyms:

Chemical Property of 2,2-bis(bromomethyl)-1,3-dioxolane

Chemical Property:

• Vapor Pressure: 0.019mmHg at 25°C
• Melting Point: 26 °C
• Boiling Point: 261.2°Cat760mmHg
• Flash Point: 103.2°C
• PSA: 18.46000
• Density: 1.887g/cm³
• LogP: 1.51930

Purity/Quality:

99% ^*data from raw suppliers

2,2-Bis(bromomethyl)-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-bis(bromomethyl)-1,3-dioxolane

There total 4 articles about 2,2-bis(bromomethyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,3-dibromoroacetone (816-39-7) + ethylene glycol (107-21-1) → 2,2-bis(bromomethyl)-1,3-dioxolane (20599-01-3)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 12h; Heating;

Reference yield: 89.0%

1,3-dibromoroacetone (816-39-7) + 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane (7381-30-8) → 2,2-bis(bromomethyl)-1,3-dioxolane (20599-01-3)

Guidance literature:

With Nafion-TMS; at 90 - 95 ℃; for 9h;

DOI:10.1002/1615-4169(200201)344:1<57::AID-ADSC57>3.0.CO;2-0

Reference yield: 71.0%

ethylene glycol (107-21-1) + acetone (67-64-1) → 2,2-bis(bromomethyl)-1,3-dioxolane (20599-01-3)

Guidance literature:

acetone; With bromine; In methanol; at 0 - 20 ℃; for 24h; Inert atmosphere;

ethylene glycol; With toluene-4-sulfonic acid; In toluene; for 24h; Inert atmosphere; Reflux; Dean-Stark;

DOI:10.1002/chem.201705306

upstream raw materials:

1,3-dibromoroacetone

ethylene glycol

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane

acetone

Downstream raw materials:

tert-butyl 3-oxoazetidine-1-carboxylate

2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octane-2-carbonitrile

Refernces

• 1、 -. "Preparation method of 3-oxazetidine-1-carboxylic acid tert-butyl ester". Paragraph 0029-0032. . Retrieved 2020/07/15.
• 2、 -. "INHIBITORS OF AKT ACTIVITY". Page/Page column 139-140. . Retrieved 2010/10/03.