1-Bromo-2,3-dimethoxybenzene

Base Information

• Chemical Name: 1-Bromo-2,3-dimethoxybenzene
• CAS No.: 5424-43-1
• Molecular Formula: C8H9BrO2
• Molecular Weight: 217.062
• Hs Code.: 2909309090
• Mol file: 5424-43-1.mol

Synonyms:1-Bromo-2,3-dimethoxybenzene;NSC 12214;NSC 123868;

Chemical Property of 1-Bromo-2,3-dimethoxybenzene

Chemical Property:

• Appearance/Colour: yellow crystal
• Vapor Pressure: 9.29E-11mmHg at 25°C
• Melting Point: 35-36 °C
• Refractive Index: 1.585
• Boiling Point: 228.1 °C at 760 mmHg
• Flash Point: 89.5 °C
• PSA: 18.46000
• Density: 1.412 g/cm³
• LogP: 2.46630
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-2,3-dimethoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Bromo-2,3-dimethoxybenzene

There total 15 articles about 1-Bromo-2,3-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(3-bromo-4,5-dimethoxyphenyl)methanol (52783-74-1) → 3-bromoveratrole (5424-43-1)

Guidance literature:

With chlorobis(cyclooctene)-iridium(I) dimer; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium chloride; In water; 1,3,5-trimethyl-benzene; at 170 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201202631

Reference yield: 85.0%

1,2-dimethoxybenzene (91-16-7) → 3-bromoveratrole (5424-43-1)

Guidance literature:

1,2-dimethoxybenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; Petroleum ether; at 20 ℃; for 2.5h; Inert atmosphere;

With bromine; In diethyl ether; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.10.011

Reference yield: 85.0%

6-bromoguaiacol (28165-49-3) + methyl iodide (74-88-4) → 3-bromoveratrole (5424-43-1)

Guidance literature:

With potassium carbonate; In acetone; at 56 ℃; for 36h;

DOI:10.1055/s-0031-1290968

upstream raw materials:

3-bromo-5-aminocatechol dimethyl ether

4-bromo-2,3-dimethoxy-aniline

1,2-dimethoxybenzene

3-bromo-1,2-dihydroxybenzene

Downstream raw materials:

1,2-dimethoxy-3-p-tolyloxy-benzene

3-bromo-1,2-dihydroxybenzene

3-bromo-5-nitrocatechol dimethyl ether

6-bromoguaiacol

Refernces

• 1、 Huet, Laurent,Forke, Ronny,J?ger, Anne,Kn?lker, Hans-Joachim. "Transition metals in organic synthesis, part 100: 1 highly efficient palladium(II)-catalyzed oxidative cyclization to the 1,7,8-trioxygenated carbazole alkaloid murrayastine". supporting information; scheme or table. p. 1230 - 1234. Retrieved 2012/06/18.
• 2、 Olsen, Esben P. K.,Madsen, Robert. "Iridium-catalyzed dehydrogenative decarbonylation of primary alcohols with the liberation of syngas". . p. 16023 - 16029. Retrieved 2013/02/22.