(3α)-Cholic acid amide

Base Information

• Chemical Name: (3α)-Cholic acid amide
• CAS No.: 6786-09-0
• Molecular Formula: C24H41NO4
• Molecular Weight: 407.594
• Mol file: 6786-09-0.mol

Synonyms:Cholsaeureamide;cholanamide;cholyl-24-amine;3α,7α,12α-trihydroxy-5β-cholan-24-amide;3α,7α,12α-trihydroxy-5β-cholanamide-(24);3α.7α.12α-Trihydroxy-5β-cholansaeure-(24)-amid;

Chemical Property of (3α)-Cholic acid amide

Chemical Property:

• PSA: 103.78000
• LogP: 3.54970

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3α)-Cholic acid amide

There total 9 articles about (3α)-Cholic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

cholic acid (81-25-4) → (3α,5β,7α,12α)3,7,12-trihydroxy-cholan-24-amide (6786-09-0)

Guidance literature:

With ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 25 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113754

Reference yield: 86.0%

methyl cholate (1448-36-8) → (3α,5β,7α,12α)3,7,12-trihydroxy-cholan-24-amide (6786-09-0)

Guidance literature:

With ammonium hydroxide; In methanol; at 100 ℃; for 120h;

Reference yield: 27.0%

glycocholic acid (475-31-0) → carbon dioxide (124-38-9,18923-20-1) + (3α,5β,7α,12α)3,7,12-trihydroxy-cholan-24-amide (6786-09-0) + oxalic acid (144-62-7,97993-78-7)

Guidance literature:

With KO₂; phase-transfer catalyst; In tetrahydrofuran; at 40 ℃; for 8h; Mechanism;

upstream raw materials:

cholic acid

3α,7α,12α-trihydroxy-5β-cholanoyl-(24)-azide

3α,7α,12α-tris-formyloxy-5β-cholan-24-oic acid amide

glycocholic acid

Downstream raw materials:

chenodeoxycholic acid

3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid

Refernces

• 1、 Lukashev, Nikolay V.,Grabovyi, Gennadii A.,Erzunov, Dmitry A.,Kazantsev, Alexey V.,Latyshev, Gennadij V.,Averin, Alexei D.,Beletskaya, Irina P.. "Pd- and Cu-catalyzed approaches in the syntheses of new cholane aminoanthraquinone pincer-like ligands". . p. 564 - 570. Retrieved 2017.
• 2、 -. "Dihydroartemisinin and steroid conjugates, and preparation method and application thereof". Paragraph 0216-0221. . Retrieved 2019/11/20.