2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid

Base Information

• Chemical Name: 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid
• CAS No.: 66662-48-4
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Hs Code.: 2933399990
• Mol file: 66662-48-4.mol

Synonyms:2-Chloro-4,6-dimethylnicotinicacid

Chemical Property of 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid

Chemical Property:

• Vapor Pressure: 2.91E-05mmHg at 25°C
• Melting Point: 139-140 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 342.3 °C at 760 mmHg
• PKA: 2.11±0.38(Predicted)
• Flash Point: 160.8 °C
• Density: 1.328 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-4,6-dimethylnicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid

There total 4 articles about 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloro-4,6-dimethylnicotinonitrile (14237-71-9) → 2-chloro-4,6-dimethylnicotinic acid (66662-48-4)

Guidance literature:

With sulfuric acid; nitric acid; In water; toluene;

Reference yield: 60.0%

2-chloro-4,6-dimethylnicotinic acid amide (140413-44-1) → 2-chloro-4,6-dimethylnicotinic acid (66662-48-4)

Guidance literature:

With sulfuric acid; sodium nitrite;

DOI:10.1023/B:COHC.0000028626.45566.67

Reference yield:

3-Cyano-4,6-dimethyl-2(1H)-pyridon (769-28-8) → 2-chloro-4,6-dimethylnicotinic acid (66662-48-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / POCl₃ / 6 h / 120 °C

2: 89 percent / aq. H₂SO₄ / Heating

3: 60 percent / H₂SO₄; aq. NaNO₂

With sulfuric acid; sodium nitrite; trichlorophosphate;

DOI:10.1023/B:COHC.0000028626.45566.67

upstream raw materials:

2-chloro-4,6-dimethylnicotinic acid amide

2-chloro-4,6-dimethylnicotinonitrile

3-Cyano-4,6-dimethyl-2(1H)-pyridon

Downstream raw materials:

methyl 2-chloro-4,6-dimethylnicotinate

2,4,6,8,11-Pentamethyl-6,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one

Refernces

• 1、 -. "Herbicidal 1-pyridyltetrazolinones". . . Retrieved 2008/06/13.