4-Biphenylethylamine, hydrochloride

Base Information

• Chemical Name: 4-Biphenylethylamine, hydrochloride
• CAS No.: 17027-69-9
• Molecular Formula: C14H15N
• Molecular Weight: 197.28
• Mol file: 17027-69-9.mol

Synonyms:4-BIPHENYLETHYLAMINE, HYDROCHLORIDE;2-(4-Biphenylyl)ethylamine hydrochloride;2-(4-phenylphenyl)ethylazanium;chloride;NSC 91617;LS-44380

Chemical Property of 4-Biphenylethylamine, hydrochloride

Chemical Property:

• Vapor Pressure: 0.0345mmHg at 25°C
• Melting Point: 50-54 °C(lit.)
• Refractive Index: 1.53
• Boiling Point: 338.1 °C at 760 mmHg
• Flash Point: 163 °C
• PSA: 26.02000
• Density: 1.031 g/cm³
• LogP: 4.35710
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 233.0971272
• Heavy Atom Count: 16
• Complexity: 164

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Biphenyl)ethylamine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)CC[NH3+].[Cl-]

Technology Process of 4-Biphenylethylamine, hydrochloride

There total 3 articles about 4-Biphenylethylamine, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-biphenylacetonitrile (31603-77-7) → 2-([1,1'-biphenyl]-4-yl)ethan-1-amine hydrochloride (17027-69-9)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether; anschliessenden Behandeln mit HCl;

DOI:10.1021/jo01106a047

Reference yield:

4-(2-nitroethenyl)-1,1'-biphenyl (62248-89-9) → 2-([1,1'-biphenyl]-4-yl)ethan-1-amine hydrochloride (17027-69-9)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether; anschliessenden Behandeln mit HCl;

Reference yield:

4-Phenylbenzaldehyde (3218-36-8) → 2-([1,1'-biphenyl]-4-yl)ethan-1-amine hydrochloride (17027-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous methanol. NaOH

2: LiAlH₄; diethyl ether / anschliessenden Behandeln mit HCl

With sodium hydroxide; lithium aluminium tetrahydride; diethyl ether;

upstream raw materials:

4-biphenylacetonitrile

4-(2-nitroethenyl)-1,1'-biphenyl

4-Phenylbenzaldehyde

Downstream raw materials:

3-(2-biphenyl-4-yl-ethylcarbamoyl)-5-trityloxycarbamoyl-pentanoic acid tert-butyl ester

C₁₅H₁₃NO

Refernces