2,2-DIMETHYL-BENZO[1,3]DIOXOL-5-YLAMINE

Base Information

• Chemical Name: 2,2-DIMETHYL-BENZO[1,3]DIOXOL-5-YLAMINE
• CAS No.: 6324-89-6
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.192
• Hs Code.: 2932999099
• Mol file: 6324-89-6.mol

Synonyms:(2,2-Dimethylbenzodioxol-5-yl)amine;3,4-Isopropylidenedioxyaniline; 5-Amino-2,2-dimethyl-1,3-benzodioxole; NSC31736

Chemical Property of 2,2-DIMETHYL-BENZO[1,3]DIOXOL-5-YLAMINE

Chemical Property:

• Vapor Pressure: 0.00732mmHg at 25°C
• Melting Point: 170.5-172℃
• Refractive Index: 1.5520 (20℃)
• Boiling Point: 138-144℃ (12 Torr)
• Flash Point: 126.3°C
• PSA: 44.48000
• Density: 1.169g/cm³
• LogP: 2.35730

Purity/Quality:

98% or more ^*data from raw suppliers

2,2-Dimethyl-2H-1,3-benzodioxol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIMETHYL-BENZO[1,3]DIOXOL-5-YLAMINE

There total 5 articles about 2,2-DIMETHYL-BENZO[1,3]DIOXOL-5-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethyl-5-nitro-1,3-benzodioxole (54186-68-4) → 2,2-dimethylbenzo[d][1,3]dioxol-5-ylamine (6324-89-6)

Guidance literature:

With 1,4-dioxane; palladium on activated charcoal; at 60 - 90 ℃; under 73550.8 Torr; Hydrogenation;

DOI:10.1002/hlca.19530360323

Reference yield:

2,2-dimethyl-1,3-benzodioxole (14005-14-2) → 2,2-dimethylbenzo[d][1,3]dioxol-5-ylamine (6324-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 60percent nitric acid / 1 h / 50 °C

2: H₂ / Adams catalyst / ethanol / 1 h

With hydrogen; nitric acid; platinum(IV) oxide; In ethanol;

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → 2,2-dimethylbenzo[d][1,3]dioxol-5-ylamine (6324-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / p-toluenesulfonic acid / benzene / 48 h / Heating

2: 95 percent / 60percent nitric acid / 1 h / 50 °C

3: H₂ / Adams catalyst / ethanol / 1 h

With hydrogen; nitric acid; toluene-4-sulfonic acid; platinum(IV) oxide; In ethanol; benzene;

upstream raw materials:

2,2-dimethyl-5-nitro-1,3-benzodioxole

2,2-dimethyl-1,3-benzodioxole

benzene-1,2-diol

Downstream raw materials:

N-(2,2-dimethylbenzo[1,3]dioxol-5-yl)acetamide

N²-cyclohexyl-3-nitro-2-aminopyridine

Refernces

• 1、 Neiland, O. Ya.,Kraupsha, I. L.,Gudele, I. Ya.. "SYNTHESIS AND SOLVATOCHROMIC AND ACID-BASE REACTIONS OF A BETAINE AND SALTS OF 4-N-PYRIDINIUMCATECHOL". . p. 1428 - 1434. Retrieved 2007/10/02.
• 2、 -. "Imidazo pyridine-2-ones and pharmaceutical compositions and methods of treatment utilizing same". . . Retrieved 2008/06/13.