4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]aniline

Base Information

• Chemical Name: 4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]aniline
• CAS No.: 7639-71-6
• Molecular Formula: C14H9F6N
• Molecular Weight: 305.223
• Mol file: 7639-71-6.mol

Synonyms:

Chemical Property of 4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]aniline

Chemical Property:

• Vapor Pressure: 0.000883mmHg at 25°C
• Boiling Point: 304.3°Cat760mmHg
• Flash Point: 137.8°C
• Density: 1.371g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]aniline

There total 10 articles about 4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-trifluoromethylphenylamine (455-14-1) + p-(trifluoromethyl)phenyl trifluoromethanesulfonate (146397-87-7) → 4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-benzenamine (7639-71-6)

Guidance literature:

With palladium diacetate; caesium carbonate; XPhos; In toluene; at 100 ℃; for 3h; Inert atmosphere; Sealed tube;

Reference yield: 93.0%

4-trifluoromethylphenylamine (455-14-1) + 4-chlorobenzotrifluoride (98-56-6) → 4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-benzenamine (7639-71-6)

Guidance literature:

With C₅₀H₇₂ClPPd; 2,6-bis(2,4,6-triisopropylphenyl)phenyldicyclohexylphosphine; potassium carbonate; In tert-butyl alcohol; at 100 ℃; for 12h; Reagent/catalyst;

DOI:10.1016/j.jcat.2021.08.017

Reference yield: 74.0%

4-Iodobenzotrifluoride (455-13-0) → 4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-benzenamine (7639-71-6)

Guidance literature:

With potassium phosphate; copper(l) iodide; lithium amide; In N,N-dimethyl-formamide; at 130 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1039/c2cc32252h

upstream raw materials:

p-trifluoromethylphenyl bromide

4-(trifluromethyl)acetanilide

4-Iodobenzotrifluoride

4-hydroxybenzotrifluoride

Downstream raw materials:

Bn-N(4-CF₃-C₆H₄)2

Refernces

• 1、 Shi, Ji-cheng,Zhang, Lixue,Zhou, Fabin. "A terphenyl phosphine as a highly efficient ligand for palladium-catalysed amination of aryl halides with 1° anilines". . p. 238 - 243. Retrieved 2021/09/07.
• 2、 -. "ORGANIC COMPOUNDS, LIGHT EMITTING DIODE AND LIGHT EMITTING DEVICE HAVING THE COMPOUNDS". Paragraph 0227-0231. . Retrieved 2020/08/07.