Nedocromil

Base Information

• Chemical Name: Nedocromil
• CAS No.: 69049-73-6
• Molecular Formula: C₁₉H₁₇NO₇
• Molecular Weight: 371.346
• European Community (EC) Number: 806-161-0
• UNII: 0B535E0BN0
• DSSTox Substance ID: DTXSID7023356
• Nikkaji Number: J32.507D
• Wikipedia: Nedocromil
• Wikidata: Q416706
• NCI Thesaurus Code: C66225
• RXCUI: 31563
• Metabolomics Workbench ID: 43024
• ChEMBL ID: CHEMBL746
• Mol file: 69049-73-6.mol

Synonyms:9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid;Alocril;Brionil;Calcium, Nedocromil;Cetimil;FPL 59002;FPL-59002;FPL59002;Halamid;Irtan;Nedocromil;Nedocromil Calcium;Nedocromil Sodium;Nedocromil, Calcium Salt (1:1);Nedocromil, Disodium Salt;Nedocromil, Disodium salt, Hydrate;Rapitil;Sodium, Nedocromil;Tilad;Tilade;Tilaire;Tilavist

Chemical Property of Nedocromil

Chemical Property:

• Vapor Pressure: 1.52E-17mmHg at 25°C
• Melting Point: 299 °C
• Refractive Index: 1.64
• Boiling Point: 645.504 °C at 760 mmHg
• PKA: 2.19±0.40(Predicted)
• Flash Point: 344.189 °C
• PSA: 126.81000
• Density: 1.472 g/cm³
• LogP: 2.47670
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble2mg/mL, clear (warmed)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 371.10050188
• Heavy Atom Count: 27
• Complexity: 753

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nedocromil >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=C2C(=CC3=C1OC(=CC3=O)C(=O)O)C(=O)C=C(N2CC)C(=O)O
• Recent ClinicalTrials: Early Airway Response to Allergen in Asthmatics (MK-0000-176)
• Uses: Antiallergic (prophylactic).
• Therapeutic Function: Antiallergic, Anti-asthmatic
• Clinical Use: Nedocromil is a chromone analogue also used by inhalation as an aerosol, primarily in the prophylaxis of asthma and reversible obstructive airway disease. It inhibits release of allergic mediators, and it is effective in a broad range of patients. An ophthalmic solution is available for the treatment of seasonal and perennial allergic conjunctivitis. Other structurally related compounds are not currently available in the United States but are available in other markets.

Technology Process of Nedocromil

There total 1 articles about Nedocromil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ nedocromil (69049-73-6)

Guidance literature:

Refernces