CHROMONE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: CHROMONE-3-CARBOXYLIC ACID
• CAS No.: 39079-62-4
• Molecular Formula: C10H6O4
• Molecular Weight: 190.155
• Hs Code.: 2916399090
• Mol file: 39079-62-4.mol

Synonyms:3-Carboxychromone;3-Chromonecarboxylic acid;4-Oxo-4H-1-benzopyran-3-carboxylic acid;4H-Chromen-4-one-3-carboxylic acid;

Chemical Property of CHROMONE-3-CARBOXYLIC ACID

Chemical Property:

• Appearance/Colour: light beige crystalline powder
• Vapor Pressure: 4.23E-05mmHg at 25°C
• Melting Point: 202-205 °C(lit.)
• Refractive Index: 1.4440 (estimate)
• Boiling Point: 337 °C at 760 mmHg
• PKA: 2.55±0.20(Predicted)
• Flash Point: 138.9 °C
• PSA: 67.51000
• Density: 1.493 g/cm³
• LogP: 1.49120
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Chromone-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Chromone-3-carboxylic acid may be used in the preparation of:chromane-2,4-dioneschromone-3-carboxamides5-(2-hydroxyphenyl)isoxazolechromone-2-carboxamideschromone-2-carboxamido-3-esters

Technology Process of CHROMONE-3-CARBOXYLIC ACID

There total 9 articles about CHROMONE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C12H11NO3 (755009-08-6) → chromone-3-carboxylic acid (39079-62-4)

Guidance literature:

With sulfuric acid; at 110 - 115 ℃; for 2h;

Reference yield: 93.0%

3-Formylchromone (17422-74-1) → chromone-3-carboxylic acid (39079-62-4)

Guidance literature:

With N-Bromosuccinimide; water; In tetrachloromethane; Irradiation;

Reference yield: 90.0%

N-methylnitrone (113326-76-4) → chromone-3-carboxylic acid (39079-62-4)

Guidance literature:

With sulfuric acid; at 110 - 115 ℃; for 2h;

upstream raw materials:

3-Formylchromone

N-methylnitrone

C₁₂H₁₁NO₃

4-oxo-4H-1-benzopyran-3-carbonitrile

Downstream raw materials:

(E)-1-(2'-hydroxyphenyl)-3-(piperidin-1-yl)prop-2-en-1-one

1-benzopyran-4(4H)-one

2,3-Dihydro-2-methoxy-4H-1-benzopyran-4-one

5,5-<3-(2'-hydroxyphenyl)-isoxazolinyl>-hydroxylamine

Refernces

• 1、 Szulawska-Mroczek, Agata,Szumilak, Marta,Szczesio, Malgorzata,Olczak, Andrzej,Nazarski, Ryszard B.,Lewgowd, Wieslawa,Czyz, Malgorzata,Stanczak, Andrzej. "Synthesis and biological evaluation of new bischromone derivatives with antiproliferative activity". . p. 34 - 43. Retrieved 2013.
• 2、 Huang, Ming,Jiang, Neng,Kong, Ling-Yi,Lan, Jin-Shuai,Wang, Xiao-Bing,Yin, Fu-Cheng. "Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease". . p. 225 - 233. Retrieved 2020/04/22.