5-Aminoquinaldine

Base Information

• Chemical Name: 5-Aminoquinaldine
• CAS No.: 54408-50-3
• Molecular Formula: C10H10N2
• Molecular Weight: 158.203
• Hs Code.: 2933499090
• Mol file: 54408-50-3.mol

Synonyms:Quinaldine,5-amino- (6CI,7CI);2-Methyl-5-quinolinamine;5-Amino-2-methylquinoline;

Chemical Property of 5-Aminoquinaldine

Chemical Property:

• Appearance/Colour: Yellow or green crystals
• Vapor Pressure: 0.000405mmHg at 25°C
• Melting Point: 117-118 °C
• Refractive Index: 1.681
• Boiling Point: 316.6 °C at 760 mmHg
• PKA: 6.39±0.50(Predicted)
• Flash Point: 171.1 °C
• PSA: 38.91000
• Density: 1.169 g/cm³
• LogP: 2.70660
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Methylquinolin-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Aminoquinaldine is used in organic synthesis and pharmaceutical intermediates.the reaction of 5-aminoquinaldine (IX) with glycerol under the conditions of the skraup reaction gave a 25% yield of 8-methyl-1,7-phenanthroline.

Technology Process of 5-Aminoquinaldine

There total 5 articles about 5-Aminoquinaldine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methyl-5-nitroquinoline (23877-94-3) → 2-methyl-5-aminoquinoline (54408-50-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 50 ℃; for 3h; under 2942.03 Torr;

DOI:10.1007/BF00809690

Reference yield:

2-methylquinoline (91-63-4) → 2-methyl-5-aminoquinoline (54408-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid monohydrate; fuming nitric acid

2: tin; concentrated hydrochloric acid

With hydrogenchloride; tin; sulfuric acid; nitric acid;

Reference yield:

aniline (62-53-3) → 2-methyl-5-aminoquinoline (54408-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrochloric acid

2: sulfuric acid monohydrate; fuming nitric acid

3: tin; concentrated hydrochloric acid

With hydrogenchloride; tin; sulfuric acid; nitric acid;

upstream raw materials:

2-methyl-5-nitroquinoline

2-methylquinoline

aniline

3-nitro-aniline

Downstream raw materials:

[(3-methoxyphenyl)methylene]-2-methylquinolin-5-amine

[1-(2,4-difluoro-3-methoxyphenyl)methylene]-2-methylquinolin-5-amine

β-[(2-methylquinolin-5-yl)imino]-α-phenyl-α-(trifluoromethyl)benzeneethanol

[(3,5-difluoro-2-methoxyphenyl)methylene]-2-methylquinolin-5-amine

Refernces

• 1、 -. "5-SUBSTITUTED QUINOLINE AND ISOQUINOLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS ANTIPHLOGISTICS". Page/Page column 28. . Retrieved 2008/06/13.
• 2、 Ferranti,Garuti,Giovanninetti,Gaggi,Roncada,Nardi. "Preparation and analgesic activity of some tetrahydroquinolines and tetrahydroisoquinolines". . p. 237 - 249. Retrieved 2007/10/02.