1-(2-methylpropyl)-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 1-(2-methylpropyl)-1H-pyrrole-2,5-dione
• CAS No.: 4120-68-7
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.181
• Mol file: 4120-68-7.mol

Synonyms:1-Isobutyl-1H-pyrrole-2,5-dione;

Chemical Property of 1-(2-methylpropyl)-1H-pyrrole-2,5-dione

Chemical Property:

• Vapor Pressure: 0.0491mmHg at 25°C
• Refractive Index: 1.501
• Boiling Point: 235.8 °C at 760 mmHg
• Flash Point: 95.5 °C
• Density: 1.117 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-methylpropyl)-1H-pyrrole-2,5-dione

There total 5 articles about 1-(2-methylpropyl)-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.1%

C8H13NO3 → 1-isobutyl-1H-pyrrole-2,5-dione (4120-68-7)

Guidance literature:

With sodium acetate; triethylamine; at 101 ℃;

DOI:10.3390/molecules23112878

Reference yield:

maleic anhydride (108-31-6) + isobutylamine (78-81-9) → 1-isobutyl-1H-pyrrole-2,5-dione (4120-68-7)

Guidance literature:

maleic anhydride; isobutylamine; With acetic acid; at 125 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In water; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00761

Reference yield:

N-(i-butyl)maleamic acid (65591-48-2) + acetic anhydride (108-24-7) → 1-isobutyl-1H-pyrrole-2,5-dione (4120-68-7) + acetic acid 1-isobutyl-2,5-dioxo-pyrrolidin-3-yl ester

Guidance literature:

With sodium acetate; at 100 ℃; Title compound not separated from byproducts;

DOI:10.1366/0003702053585426

upstream raw materials:

N-(i-butyl)maleamic acid

acetic anhydride

maleic anhydride

isobutylamine

Refernces

• 1、 Li, Shanshan,Song, Gao,Wang, Liang-Liang,Weng, Zhiying,Xu, Guowei,Yang, Weimin,Yang, Yanming,Yang, Yaqing,Zhang, Jiajun,Zuo, Zhili. "The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation". supporting information. . Retrieved 2020/02/27.
• 2、 Hosseini-Sarvari, Mona,Koohgard, Mehdi,Firoozi, Somayeh,Mohajeri, Afshan,Tavakolian, Hosein. "Alizarin red S-TiO2-catalyzed cascade C(sp3)-H to C(sp2)-H bond formation/cyclization reactions toward tetrahydroquinoline derivatives under visible light irradiation". supporting information. p. 6880 - 6888. Retrieved 2018/05/04.