(3,4-DIMETHOXYBENZYL)METHYLAMINE

Base Information

• Chemical Name: (3,4-DIMETHOXYBENZYL)METHYLAMINE
• CAS No.: 63-64-9
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Hs Code.: 2922299090
• Mol file: 63-64-9.mol

Synonyms:Veratrylamine,N-methyl- (6CI,7CI,8CI);N-Methyl-3,4-dimethoxybenzylamine;N-Methylveratrylamine;3,4-Dimethoxy-N-methylbenzylamine;N-(3,4-Dimethoxybenzyl)-N-methylamine;

Chemical Property of (3,4-DIMETHOXYBENZYL)METHYLAMINE

Chemical Property:

• Vapor Pressure: 0.0165mmHg at 25°C
• Refractive Index: n20/D 1.5410(lit.)
• Boiling Point: 103-106 °C0.5 mm Hg(lit.)
• PKA: 9.29±0.10(Predicted)
• Flash Point: >230 °F
• PSA: 30.49000
• Density: 0.951 g/mL at 25 °C(lit.)
• LogP: 1.81410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

90.0%Min ^*data from raw suppliers

(3,4-Dimethoxybenzyl)methylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of (3,4-DIMETHOXYBENZYL)METHYLAMINE

There total 14 articles about (3,4-DIMETHOXYBENZYL)METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ N-methylveratrylamine (63-64-9)

Guidance literature:

Reference yield: 94.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + methylamine (74-89-5) → N-methylveratrylamine (63-64-9)

Guidance literature:

3,4-dimethoxy-benzaldehyde; methylamine; In methanol; water; at 23 ℃; for 1h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; water; at 23 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.12.073

Reference yield:

C15H23NO4 (1470522-09-8) → N-methylveratrylamine (63-64-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 8h;

DOI:10.1016/j.bmcl.2014.05.022

upstream raw materials:

3,4-dimethoxy-benzaldehyde

methylamine

4-chloromethyl-1,2-dimethoxy-benzene

3,4-dimethoxy-N-methylbenzamide

Downstream raw materials:

(3,4-Dimethoxy-benzyl)-methyl-[3-(4-nitro-phenyl)-propyl]-amine

(3,4-Dimethoxy-benzyl)-methyl-[3-(4-nitro-phenoxy)-propyl]-amine

(3,4-Dimethoxy-benzyl)-methyl-[4-(4-nitro-phenyl)-butyl]-amine

N-(3,4-Dimethoxy-benzyl)-N-methyl-3-(4-nitro-phenyl)-propionamide

Refernces

• 1、 Park, Sun You,Oh, Yong Jin,Lho, Yunmee,Jeong, Ju Hui,Liu, Kwang-Hyeon,Song, Jaeyoung,Kim, Soong-Hyun,Ha, Eunyoung,Seo, Young Ho. "Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors". . p. 390 - 401. Retrieved 2017/12/07.
• 2、 Singh, Kawaljit,Kumar, Malkeet,Pavadai, Elumalai,Naran, Krupa,Warner, Digby F.,Ruminski, Peter G.,Chibale, Kelly. "Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c". . p. 2985 - 2990. Retrieved 2014/06/24.