8-BROMOHYPOXANTHINE

Base Information

• Chemical Name: 8-BROMOHYPOXANTHINE
• CAS No.: 56046-36-7
• Molecular Formula: C5H3 Br N4 O
• Molecular Weight: 215.01
• Hs Code.: 2933998090
• Mol file: 56046-36-7.mol

Synonyms:6H-Purin-6-one,8-bromo-1,7-dihydro- (9CI); Hypoxanthine, 8-bromo- (7CI); 8-Bromohypoxanthine;NSC 112525; SQ 22055

Chemical Property of 8-BROMOHYPOXANTHINE

Chemical Property:

• Vapor Pressure: 0.00116mmHg at 25°C
• Melting Point: >300 °C
• Boiling Point: 299.8°Cat760mmHg
• PKA: 7.95±0.20(Predicted)
• Flash Point: 135.1°C
• PSA: 74.43000
• Density: 2.54g/cm³
• LogP: 0.40870

Purity/Quality:

99% ^*data from raw suppliers

8-Bromo-1,7-dihydropurin-6-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-BROMOHYPOXANTHINE

There total 5 articles about 8-BROMOHYPOXANTHINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

8-bromoadenine (6974-78-3) → 8-bromohypoxanthine (56046-36-7)

Guidance literature:

With dinitrogen trioxide; acetic acid; for 1h; Ambient temperature;

DOI:10.1002/jhet.5570220303

Reference yield: 30.0%

8-bromo-2'-deoxyinosine (916735-48-3) → 9-((2R,4S)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one + 9-((2R,4S)-5-Dihydroxymethyl-4-hydroxy-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one + (5'R)-5',8-cyclo-2'-deoxyinosine + 8-bromohypoxanthine (56046-36-7)

Guidance literature:

In water; for 3h; pH=4 - 7; Further byproducts given;

DOI:10.1002/chem.200600040

Reference yield:

8-bromo-2'-deoxyadenosine (14985-44-5,90968-89-1) → 8-bromohypoxanthine (56046-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite / acetic acid / 1.5 h

2: 28 percent / H₂O / 3 h / pH 4 - 7

With sodium nitrite; In water; acetic acid;

DOI:10.1002/chem.200600040

upstream raw materials:

8-bromoadenine

8-bromo-2'-deoxyinosine

8-bromo-2'-deoxyadenosine

Refernces

• 1、 Robins,Revankar,O'Brien,et al.. "Purine analog inhibitors of xanthine oxidase - Structure activity relationships and proposed binding of the molybdenum cofactor". . p. 601 - 634. Retrieved 2007/10/02.