Cetohexazine

Base Information

• Chemical Name: Cetohexazine
• CAS No.: 7007-92-3
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14
• Hs Code.: 2933998090
• Mol file: 7007-92-3.mol

Synonyms:4,6-Dimethyl-3(2H)-pyridazinone;Ketohexazine;Cetohexazin;Cetohexazine;

Chemical Property of Cetohexazine

Chemical Property:

• Refractive Index: 1.563
• PSA: 46.01000
• Density: 1.17g/cm³
• LogP: 0.79900

Purity/Quality:

NLT 98% ^*data from raw suppliers

4,6-dimethyl-2,3-dihydropyridazin-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cetohexazine

There total 6 articles about Cetohexazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-diethoxyphosphoryl-6-methylpyridazin-3(2H)-one (1027102-66-4) → 4,6-dimethyl-2,3-dihydropyridazin-3-one (7007-92-3)

Guidance literature:

4-diethoxyphosphoryl-6-methylpyridazin-3(2H)-one; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

formaldehyd; In tetrahydrofuran; for 1.5h; Reflux;

DOI:10.1039/b718734c

Reference yield:

→ 4,6-dimethyl-2,3-dihydropyridazin-3-one (7007-92-3)

Guidance literature:

With bromine; acetic acid;

DOI:10.1021/ja01583a043

Reference yield:

2-Hydroxy-4-oxo-2-methyl-pentansaeure (81416-97-9) → 4,6-dimethyl-2,3-dihydropyridazin-3-one (7007-92-3)

Guidance literature:

With hydrazine hydrate; In butan-1-ol; Heating;

DOI:10.1021/jm00123a004

upstream raw materials:

2-methyl-4-oxo-pent-2c-enoic acid

2-Hydroxy-4-oxo-2-methyl-pentansaeure

4,5-dihydro-4,6-dimethylpyridazin-3(2H)-one

2-methyl-4-oxopentanoic acid

Downstream raw materials:

(4,6-Dimethyl-pyridazin-3-yl)-(2-morpholin-4-yl-ethyl)-amine; hydrochloride

3-chloro-4,6-dimethylpyridazine

Refernces

• 1、 Hu, Wenhui,Ralay Ranaivo, Hantamalala,Roy, Saktimayee M.,Behanna, Heather A.,Wing, Laura K.,Munoz, Lenka,Guo, Ling,Van Eldik, Linda J.,Watterson, D. Martin. "Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits". . p. 414 - 418. Retrieved 2007/10/03.