3-(CYCLOPROPYLAMINO)PROPIONITRILE

Base Information

• Chemical Name: 3-(CYCLOPROPYLAMINO)PROPIONITRILE
• CAS No.: 58196-47-7
• Molecular Formula: C6H10N2
• Molecular Weight: 110.159
• Mol file: 58196-47-7.mol

Synonyms:3-(Cyclopropylamino)propanenitrile;3-(Cyclopropylamino)propionitrile;N-(2-Cyanoethyl)-N-(cyclopropyl)amine;

Chemical Property of 3-(CYCLOPROPYLAMINO)PROPIONITRILE

Chemical Property:

• Vapor Pressure: 0.049mmHg at 25°C
• Refractive Index: n20/D 1.4550(lit.)
• Boiling Point: 235.8 °C at 760 mmHg
• PKA: 6.97±0.20(Predicted)
• Flash Point: 96.4 °C
• PSA: 35.82000
• Density: 0.98g/cm³
• LogP: 1.04298

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(cyclopropylamino)propanenitrile ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-(CYCLOPROPYLAMINO)PROPIONITRILE

There total 3 articles about 3-(CYCLOPROPYLAMINO)PROPIONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

acrylonitrile (107-13-1,25014-41-9) + Cyclopropylamine (765-30-0) → 3-Cyclopropylamino-propionitrile (58196-47-7)

Guidance literature:

With Ps-AlCl₃; at 70 ℃; for 2h; enantioselective reaction;

DOI:10.1016/j.tet.2012.12.037

Reference yield:

→ 3-(benzylamino)propionitrile (706-03-6) + 3-Cyclopropylamino-propionitrile (58196-47-7)

Guidance literature:

Reference yield:

→ 3-Cyclopropylamino-propionitrile (58196-47-7)

Guidance literature:

Acrylnitril, Cyclopropylamin;

upstream raw materials:

acrylonitrile

Cyclopropylamine

Downstream raw materials:

tert-butyl 3-aminopropyl(cyclopropyl)carbamate

4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({4-[(2-cyanoethyl)(cyclopropyl)amino]cyclohexyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide

tert-butyl 4-((2-cyanoethyl)(cyclopropyl)amino)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

3-((6-acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)(cyclopropyl)amino)propanenitrile

Refernces

• 1、 Dai, Liyan,Zhang, Yi,Dou, Qianqian,Wang, Xiaozhong,Chen, Yingqi. "Chemo/regioselective Aza-Michael additions of amines to conjugate alkenes catalyzed by polystyrene-supported AlCl3". . p. 1712 - 1716. Retrieved 2013/03/13.
• 2、 -. "Pyrrolidine derivatives". . . Retrieved 2008/06/13.