La 201

Base Information

• Chemical Name: La 201
• CAS No.: 53555-73-0
• Molecular Formula: C₁₉H₁₇NO₂
• Molecular Weight: 291.349
• Mol file: 53555-73-0.mol

Synonyms:

Chemical Property of La 201

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of La 201

There total 4 articles about La 201 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(4-methoxyphenyl)(pyridin-2-yl)methanol (27805-39-6) + phenol (108-95-2,27073-41-2) → 4-((4-methoxyphenyl)(pyridin-2-yl)methyl)phenol (53555-73-0)

Guidance literature:

With sulfuric acid; In nitrobenzene; at 0 ℃; for 0.0833333h;

DOI:10.1016/j.bioorg.2020.103591

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 4-((4-methoxyphenyl)(pyridin-2-yl)methyl)phenol (53555-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: sulfuric acid / nitrobenzene / 0.08 h / 0 °C

With sulfuric acid; isopropylmagnesium chloride; In tetrahydrofuran; nitrobenzene;

DOI:10.1016/j.bioorg.2020.103591

Reference yield:

2-bromo-pyridine (109-04-6) → 4-((4-methoxyphenyl)(pyridin-2-yl)methyl)phenol (53555-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: sulfuric acid / nitrobenzene / 0.08 h / 0 °C

With sulfuric acid; isopropylmagnesium chloride; In tetrahydrofuran; nitrobenzene;

DOI:10.1016/j.bioorg.2020.103591

upstream raw materials:

(4-methoxyphenyl)(pyridin-2-yl)methanol

phenol

pyridine-2-carbaldehyde

4-methoxy-benzaldehyde

Refernces