Benzaldehyde, 2-hydroxy-, hydrazone

Base Information

• Chemical Name: Benzaldehyde, 2-hydroxy-, hydrazone
• CAS No.: 3291-00-7
• Molecular Formula: C7H8 N2 O
• Molecular Weight: 136.153
• Hs Code.: 2928000090
• Mol file: 3291-00-7.mol

Synonyms:2-Hydroxybenzaldehyde hydrazone;SCHEMBL2316554;FT-0634762;(6E)-6-(hydrazinylmethylidene)cyclohexa-2,4-dien-1-one

Chemical Property of Benzaldehyde, 2-hydroxy-, hydrazone

Chemical Property:

• Appearance/Colour: slightly yellow shiny flakes
• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 97-98 °C(lit.)
• Boiling Point: 292.109°C at 760 mmHg
• PKA: 8.72±0.35(Predicted)
• Flash Point: 130.463°C
• PSA: 58.61000
• Density: 1.181g/cm³
• LogP: 1.38510
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 125

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-HydroxybenzaldehydeHydrazone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=NN)O

Technology Process of Benzaldehyde, 2-hydroxy-, hydrazone

There total 20 articles about Benzaldehyde, 2-hydroxy-, hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

salicylaldehyde (90-02-8) → 2-(hydrazonomethyl)phenol (3291-00-7)

Guidance literature:

With hydrazine hydrate; In methanol; for 3h; Reflux;

DOI:10.1016/j.bmc.2014.07.022

Reference yield: 79.8%

2-methyl-benzyl alcohol (89-95-2) → 2-(hydrazonomethyl)phenol (3291-00-7)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 1.16667h;

DOI:10.3390/81200894

Reference yield: 40.0%

3-acetylcoumarin (3949-36-8) → salicyaldehyde azine (959-36-4) + 2-(hydrazonomethyl)phenol (3291-00-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 24h; Ambient temperature;

upstream raw materials:

salicylaldehyde

3-acetylcoumarin

N-((1S,2R,3S,4R)-1-Hydrazonomethyl-2,3,4,5-tetrahydroxy-pentyl)-acetamide

ethanol

Downstream raw materials:

chloro-acetic acid salicylidenehydrazide

o-Hydroxybenzaldehyd-p-nitrophenyl-semicarbazon

o-Hydroxy-benzaldehyd-m-nitrophenyl-semicarbazon

o-Hydroxybenzaldehyd-o-nitro-phenyl-semicarbazon

Refernces

• 1、 Belal, Arafa A.M.,Zayed,El-Desawy,Rakha, Sh.M.A.H.. "Structure investigation of three hydrazones Schiff's bases by spectroscopic, thermal and molecular orbital calculations and their biological activities". . p. 49 - 57. Retrieved 2015.
• 2、 Tiwari, Karishma,Kumar, Sumit,Kumar, Vipan,Kaur, Jeevanjot,Arora, Saroj,Mahajan, Rakesh Kumar. "An azine based sensor for selective detection of Cu2 + ions and its copper complex for sensing of phosphate ions in physiological conditions and in living cells". . p. 16 - 26. Retrieved 2018.
• 3、 -. "Fluorescent molecule, preparation method thereof, application thereof and fluorescence detection reagent (by machine translation)". Paragraph 0092; 0103-0106; 0111; 0117. . Retrieved 2019/12/02.