3-FLUORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE

Base Information

• Chemical Name: 3-FLUORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE
• CAS No.: 188815-30-7
• Molecular Formula: C8H4 F4 O
• Molecular Weight: 192.113
• Hs Code.: 29130000
• Mol file: 188815-30-7.mol

Synonyms:3-Fluoro-5-(trifluoromethyl)benzaldehyde;3-Trifluoromethyl-5-fluorobenzaldehyde

Chemical Property of 3-FLUORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE

Chemical Property:

• Vapor Pressure: 1.48mmHg at 25°C
• Refractive Index: n20/D 1.45(lit.)
• Boiling Point: 170.3°Cat760mmHg
• Flash Point: 61.4°C
• PSA: 17.07000
• Density: 1.383g/cm³
• LogP: 2.65700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

98% ^*data from raw suppliers

3-Fluoro-5-(trifluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-FLUORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE

There total 1 articles about 3-FLUORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

3-Trifluoromethylbenzaldehyde (454-89-7) → m-(trifluoromethyl)benzoyl fluoride (328-99-4) + 3-fluoro-5-(trifluoromethyl)benzaldehyde (188815-30-7)

Guidance literature:

With fluorine; In acetonitrile; at 0 ℃; Inert atmosphere;

DOI:10.1021/op700194r

Reference yield: 98.0%

(S)-tert-butyl 5-amino-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate (872624-62-9) + 3-fluoro-5-(trifluoromethyl)benzaldehyde (188815-30-7) → (S)-5-(3-fluoro-5-trifluoromethyl-benzylamino)-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-benzo[6]azepine-1-carboxylic acid tert-butyl ester (872626-73-8)

Guidance literature:

(S)-tert-butyl 5-amino-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate; 3-fluoro-5-(trifluoromethyl)benzaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 20h;

With water; sodium hydrogencarbonate; In 1,2-dichloro-ethane;

Reference yield: 86.0%

3-fluoro-5-(trifluoromethyl)benzaldehyde (188815-30-7) + (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyl-10-((2S,3R,4S,6R)-3-hydroxy-6-methyl-4-methylamino-tetrahydro-pyran-2-yloxy)-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-butyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone (255918-54-8) → 4-ethyl-10-{4-[(3-fluoro-5-trifluoromethyl-benzyl)-methyl-amino]-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy}-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-butyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Guidance literature:

3-fluoro-5-(trifluoromethyl)benzaldehyde; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyl-10-((2S,3R,4S,6R)-3-hydroxy-6-methyl-4-methylamino-tetrahydro-pyran-2-yloxy)-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-butyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone; In methanol; acetic acid; at 20 ℃; for 0.5h;

With borane pyridine; for 8h;

DOI:10.1016/S0040-4039(02)00746-3

upstream raw materials:

3-Trifluoromethylbenzaldehyde

Downstream raw materials:

N-{5-ethyl-4-[(3-fluoro-5-trifluoromethyl-phenyl)-hydroxy-methyl]-2-methoxy-6-methyl-pyridin-3-yl}-2,2-dimethyl-propionamide

trans 3-(3-trifluoromethyl-5-fluorophenyl)-2-propenoic acid methyl ester

3-amino-5-ethyl-4-(3-fluoro-5-trifluoromethyl-benzoyl)-6-methyl-1H-pyridin-2-one

N-[5-ethyl-4-(3-fluoro-5-trifluoromethyl-benzoyl)-2-methoxy-6-methyl-pyridin-3-yl]-2,2-dimethyl-propionamide

Refernces