Methyl orotate

Base Information Edit

Chemical Name:Methyl orotate
CAS No.:6153-44-2
Molecular Formula:C6H6N2O4
Molecular Weight:170.125
Hs Code.:29349990
European Community (EC) Number:228-171-9
NSC Number:42009
UNII:41C6IFG4MQ
DSSTox Substance ID:DTXSID20210523
Nikkaji Number:J208.826F
Wikidata:Q27258430
ChEMBL ID:CHEMBL1742079
Mol file:6153-44-2.mol

Synonyms:Methyl orotate;6153-44-2;methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate;Orotic acid methyl ester;methyl 2,4-dioxo-1H-pyrimidine-6-carboxylate;Methylorotate;4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, methyl ester;NSC42009;6-Carbomethyoxyuracil;MFCD00010564;NSC-42009;UNII-41C6IFG4MQ;41C6IFG4MQ;methyl 2,6-dihydroxy-4-pyrimidinecarboxylate;methyl 2,6-dihydroxypyrimidine-4-carboxylate;EINECS 228-171-9;NSC 42009;Methyl 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate;6-carbomethoxyuracil;NCIStruc1_000207;NCIStruc2_000053;SCHEMBL118496;CHEMBL1742079;UUTDWTOZAWFKFW-UHFFFAOYSA-;DTXSID20210523;NCI42009;BBL104241;CCG-36855;NCGC00013491;STL488929;STL558338;AKOS004910879;AKOS024302265;OROTIC ACID METHYL ESTER [MI];SB57794;NCGC00013491-02;NCGC00096605-01;AC-25667;DS-15188;NCI60_003952;SY018105;AM20120684;CS-0008570;FT-0628769;methyl 2,6-dioxo-3H-pyrimidine-4-carboxylate;Q27258430;2,6-dioxo-3H-pyrimidine-4-carboxylic acid methyl ester;Methyl 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylate;Methyl 2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylate #

Suppliers and Price of Methyl orotate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MethylOrotate
10g
$ 195.00

SynQuest Laboratories
Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
5 g
$ 135.00

SynQuest Laboratories
Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
1 g
$ 45.00

SynQuest Laboratories
Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
25 g
$ 495.00

Medical Isotopes, Inc.
MethylOrotate
10 g
$ 675.00

Matrix Scientific
Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
25g
$ 150.00

Matrix Scientific
Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
1g
$ 22.00

Matrix Scientific
Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
5g
$ 60.00

Crysdot
Methyl2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate 95+%
100g
$ 347.00

Chemenu
Methyl2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate 95%
100g
$ 327.00

Total 54 raw suppliers

Chemical Property of Methyl orotate Edit

Chemical Property:

Appearance/Colour:yellow to light brown crystalline powder
Melting Point:244 °C
Refractive Index:1.509
Boiling Point:299.73°C (rough estimate)
PKA:5.42±0.10(Predicted)
PSA：92.02000
Density:1.412 g/cm³
LogP:-1.15020
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:170.03275668
Heavy Atom Count:12
Complexity:281

Purity/Quality:

99% ^*data from raw suppliers

MethylOrotate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 37/39-26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC(=O)NC(=O)N1
Uses Methyl Orotate is used in the synthesis of pyrrimidine hydrazine acids used in peptide recognition. Also used in the preparation of pyrimidines bearing an acyclic moiety.

Technology Process of Methyl orotate

There total 12 articles about Methyl orotate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 67-56-1
methanol

: 65-86-1
2,4-dihydroxypyrimidine-6-carboxylic acid

: 6153-44-2
2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid methyl ester

Guidance literature:: 2,4-dihydroxypyrimidine-6-carboxylic acid; With pyridine; thionyl chloride; N,N-dimethyl-formamide; at 20 ℃; Reflux;

methanol; Reflux;