Technology Process of 1H-Pyrrolizine-1-methoanol, 7-(acetyloxy)hexahydro, acetate (ester), (1S-(1alpha,7alpha,7abeta))-
There total 13 articles about 1H-Pyrrolizine-1-methoanol, 7-(acetyloxy)hexahydro, acetate (ester), (1S-(1alpha,7alpha,7abeta))- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 17 percent / 25 h / Ambient temperature
2: NaOH / methanol; H2O / 2 h / 0 - 20 °C
3: 96 percent / H2 / 5percent Pd/C / ethanol / 42 h / 2585.7 Torr / Ambient temperature
4: 94 percent / pyridine / 2.5 h / Ambient temperature
5: 85 percent / HgO, I2 / CCl4 / 3 h / 85 °C
6: 91 percent / tri-n-butyltyin hydride, AIBN / toluene / 0.5 h / 80 °C
7: LiAlH4 / tetrahydrofuran / 0.5 h / Heating
With
pyridine; sodium hydroxide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); hydrogen; iodine; tri-n-butyl-tin hydride; mercury(II) oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; toluene;
DOI:10.1021/jo00202a016
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 83 percent / NaBH4 / methanol / 0.33 h / -25 °C
2: 17 percent / 25 h / Ambient temperature
3: NaOH / methanol; H2O / 2 h / 0 - 20 °C
4: 96 percent / H2 / 5percent Pd/C / ethanol / 42 h / 2585.7 Torr / Ambient temperature
5: 94 percent / pyridine / 2.5 h / Ambient temperature
6: 85 percent / HgO, I2 / CCl4 / 3 h / 85 °C
7: 91 percent / tri-n-butyltyin hydride, AIBN / toluene / 0.5 h / 80 °C
8: LiAlH4 / tetrahydrofuran / 0.5 h / Heating
With
pyridine; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); hydrogen; iodine; tri-n-butyl-tin hydride; mercury(II) oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; toluene;
DOI:10.1021/jo00202a016
- Guidance literature:
-
Multi-step reaction with 9 steps
1: acetyl chloride / CH2Cl2 / 30 h / 40 °C
2: 83 percent / NaBH4 / methanol / 0.33 h / -25 °C
3: 17 percent / 25 h / Ambient temperature
4: NaOH / methanol; H2O / 2 h / 0 - 20 °C
5: 96 percent / H2 / 5percent Pd/C / ethanol / 42 h / 2585.7 Torr / Ambient temperature
6: 94 percent / pyridine / 2.5 h / Ambient temperature
7: 85 percent / HgO, I2 / CCl4 / 3 h / 85 °C
8: 91 percent / tri-n-butyltyin hydride, AIBN / toluene / 0.5 h / 80 °C
9: LiAlH4 / tetrahydrofuran / 0.5 h / Heating
With
pyridine; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); hydrogen; iodine; tri-n-butyl-tin hydride; acetyl chloride; mercury(II) oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jo00202a016