4-Methyl-2-phenylpyridine

Base Information

• Chemical Name: 4-Methyl-2-phenylpyridine
• CAS No.: 3475-21-6
• Molecular Formula: C12H11N
• Molecular Weight: 169.226
• Hs Code.: 2933399090
• European Community (EC) Number: 222-448-8
• DSSTox Substance ID: DTXSID50188302
• Nikkaji Number: J216.144C
• Wikidata: Q72495223
• Mol file: 3475-21-6.mol

Synonyms:4-Methyl-2-phenylpyridine;3475-21-6;2-Phenyl-4-picoline;2-phenyl-4-methylpyridine;EINECS 222-448-8;2-Phenyl-4-methyl-pyridine;SCHEMBL842170;Pyridine, 4-methyl-2-phenyl-;DTXSID50188302;AMY10507;MFCD00087695;AKOS006272695;AC-20681;DS-18129;CS-0095760;FT-0634873;M2952;F52194;A822382;AO-801/41077420

Chemical Property of 4-Methyl-2-phenylpyridine

Chemical Property:

• Vapor Pressure: 0.0051mmHg at 25°C
• Melting Point: 47.0 to 51.0 °C
• Refractive Index: 1.568
• Boiling Point: 284.5 °C at 760 mmHg
• PKA: 5.06±0.10(Predicted)
• Flash Point: 119.1 °C
• PSA: 12.89000
• Density: 1.03 g/cm³
• LogP: 3.05700
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 169.089149355
• Heavy Atom Count: 13
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

4-Methyl-2-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1)C2=CC=CC=C2

Technology Process of 4-Methyl-2-phenylpyridine

There total 55 articles about 4-Methyl-2-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Bromo-4-picoline (4926-28-7) + phenylboronic acid (98-80-6) → 4-methyl-2-phenylpyridine (3475-21-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In tetrahydrofuran; at 60 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tet.2018.10.075

Reference yield: 95.0%

2-Bromo-4-picoline (4926-28-7) + phenylmagnesium chloride (100-59-4) → 4-methyl-2-phenylpyridine (3475-21-6)

Guidance literature:

1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at -25 ℃; for 18h;

DOI:10.1016/S0040-4020(02)00411-8

Reference yield: 91.0%

2-Bromo-4-picoline (4926-28-7) + triphenylbismuthane (603-33-8) → 4-methyl-2-phenylpyridine (3475-21-6)

Guidance literature:

With potassium acetate; palladium diacetate; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201402455

upstream raw materials:

picoline

diethyl ether

phenyllithium

benzonitrile

Downstream raw materials:

2-phenylpyridine-4-carboxylic acid

1,4-dimethyl-2-phenylpyridin-1-ium iodide

2-(2-phenylpyridin-4-yl)-1-(pyridin-2-yl)ethanone

4-[p-(diethylamino)styryl]-2-phenylpyridine

Refernces

• 1、 Thathong, Yuranan,Chasing, Pongsakorn,Manyum, Thanaporn,Namuangruk, Supawadee,Saengsuwan, Sayant,Sudyoasuk, Taweesak,Promarak, Vinich. "Enhancement of the electroluminescence properties of iridium-complexes by decorating the ligand with hole-transporting carbazole dendrons". . p. 7694 - 7704. Retrieved 2021.
• 2、 -. "gamma-alkenyl ketone and preparation method thereof". . . Retrieved 2020/02/29.