3,4-Dihydroxybenzohydrazide

Base Information

• Chemical Name: 3,4-Dihydroxybenzohydrazide
• CAS No.: 39635-11-5
• Molecular Formula: C7H8N2O3
• Molecular Weight: 168.152
• Hs Code.: 2928000090
• European Community (EC) Number: 254-550-3
• DSSTox Substance ID: DTXSID90192741
• Nikkaji Number: J261.408A
• Wikidata: Q83065406
• Mol file: 39635-11-5.mol

Synonyms:3,4-Dihydroxybenzohydrazide;3,4-Dihydroxybenzhydrazide;39635-11-5;EINECS 254-550-3;protocatechuhydrazide;3,4-dihydroxy-benzoic acid hydrazide;3,4-Dihydroxy-benzohydrazide;SCHEMBL2664433;DTXSID90192741;3,4-dihydroxybenzoic acid hydrazide;3,4-Dihydroxy-benzoesaeure-hydrazid;MFCD00017064;3,4-dihydroxybenzoic acid, hydrazide;AKOS006228190;SB86072;3,4-Dihydroxybenzohydrazide, AldrichCPR;AS-11535;Benzoic acid, 3,4-dihydroxy-, hydrazide;CS-0149904;FT-0614325;D94702;EN300-185843;A824659

Chemical Property of 3,4-Dihydroxybenzohydrazide

Chemical Property:

• Melting Point: 268 °C
• Refractive Index: 1.67
• PSA: 95.58000
• Density: 1.477 g/cm³
• LogP: 0.79250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 168.05349212
• Heavy Atom Count: 12
• Complexity: 174

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dihydroxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1C(=O)NN)O)O

Technology Process of 3,4-Dihydroxybenzohydrazide

There total 6 articles about 3,4-Dihydroxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.9%

Ethyl protocatechuate (3943-89-3) → 3,4-dihydroxy-benzoic acid hydrazide (39635-11-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 60 ℃; for 6h;

Reference yield: 82.3%

→ 3,4-dihydroxy-benzoic acid hydrazide (39635-11-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

Reference yield: 66.0%

3,4-dihydroxybenzoic acid methyl ester (2150-43-8) → 3,4-dihydroxy-benzoic acid hydrazide (39635-11-5)

Guidance literature:

With hydrazine hydrate; Reflux;

DOI:10.2174/1573406416666200602152643

upstream raw materials:

Ethyl protocatechuate

3,4-dihydroxybenzoic acid methyl ester

3,4-Dihydroxybenzoic acid

3,4-dihydroxybenzoyl chloride

Downstream raw materials:

1,2-bis((5-nitrofuran-2-yl)methylene)hydrazine

Refernces

• 1、 Bogdanovi?, Goran A.,Brankovi?, Jovica,Milovanovi?, Vesna,Mladenovi?, Milan,Novakovi?, Sla?ana,Petrovi?, Vladimir P.,Petrovi?, Zorica D.,Simijonovi?, Du?ica. "Pyrazole derivatives of medically relevant phenolic acids: Insight into antioxidative and anti-lox activity". . p. 807 - 819. Retrieved 2021/10/21.
• 2、 -. "Aromatic acyl hydrazone derivative and application thereof as NA inhibitor". Paragraph 0039; 0044-0046; 0323-0327. . Retrieved 2020/12/30.