3'-HYDROXYPROPIOPHENONE

Base Information

• Chemical Name: 3'-HYDROXYPROPIOPHENONE
• CAS No.: 5650-41-9
• Molecular Formula: C9H10O2
• Molecular Weight: 150.177
• Hs Code.: 2914400090
• Mol file: 5650-41-9.mol

Synonyms:2benzoylethanol

Chemical Property of 3'-HYDROXYPROPIOPHENONE

Chemical Property:

• Melting Point: 24°C
• Refractive Index: 1.5450 (estimate)
• Boiling Point: 231.72°C (rough estimate)
• PKA: 14.37±0.10(Predicted)
• PSA: 37.30000
• Density: 1.1078
• LogP: 1.98490

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxy-1-phenylpropan-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-HYDROXYPROPIOPHENONE

There total 75 articles about 3'-HYDROXYPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-styrenyloxytrimethylsilane (13735-81-4) → 3-hydroxy-1-phenylpropan-1-one (5650-41-9)

Guidance literature:

With indium(III) chloride; In water; at 23 ℃; for 15h;

DOI:10.1039/cc9960001819

Reference yield: 89.0%

2,3-epoxy-1-phenylpropan-1-one (5650-34-0) → 3-hydroxy-1-phenylpropan-1-one (5650-41-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 98 ℃; for 1h;

DOI:10.1021/jo00046a016

Reference yield: 81.8%

4-phenyl-1,3-dioxane (772-00-9,99494-18-5) → 3-hydroxy-1-phenylpropan-1-one (5650-41-9)

Guidance literature:

With sodium bicarbonate; sodium chloride; hydrogen bromide; dihydrogen peroxide; sodium sulfite; In dichloromethane; water;

upstream raw materials:

3-Bromopropionic acid

3-acetoxypropiophenone

2-methyl-3-phenyl-2-cyclopentenone

3-Phenyl-2-propyn-1-ol

Downstream raw materials:

N,N-bis-(3-hydroxyimino-3-phenyl-propyl)-hydroxylamine

C₂₁H₂₀O₂Si

N,N-bis-(3-oxo-3-phenyl-propyl)-hydroxylamine

(S)-3-phenyl-1,3-propanediol

Refernces

• 1、 Sommer, Florian,Kappe, C. Oliver,Cantillo, David. "Chemoselective Electrochemical Oxidation of Secondary Alcohols Using a Recyclable Chloride-Based Mediator". supporting information. p. 166 - 170. Retrieved 2021/06/16.
• 2、 Uraguchi, Daisuke,Kato, Kohsuke,Ooi, Takashi. "o-Quinone methide with overcrowded olefin component as a dehydridation catalyst under aerobic photoirradiation conditions". . p. 2778 - 2783. Retrieved 2021/03/14.