Oxiconazole

Base Information

• Chemical Name: Oxiconazole
• CAS No.: 64211-45-6
• Molecular Formula: C₁₈H₁₃Cl₄N₃O
• Molecular Weight: 429.133
• Hs Code.: 2933290090
• UNII: C668Q9I33J
• DSSTox Substance ID: DTXSID8040690
• Wikipedia: Oxiconazole
• NCI Thesaurus Code: C61869
• RXCUI: 32638
• Pharos Ligand ID: W6DT9YA766FB
• ChEMBL ID: CHEMBL1262
• Mol file: 64211-45-6.mol

Synonyms:(Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-O-(2,4-dichlorobenzyl) ethanone oxime nitrate;2',4'-dichloro-2-imidazol-1-ylacetophenone (Z)-(O-(2,4-dichlorobenzyl)oxime), mononitrate;Fonx;Gyno-Myfungar;Myfungar;Oceral;oxiconazole;oxiconazole mononitrate, (Z)-isomer;oxiconazole nitrate;Oxistat;Oxizole;oxyconazole;RO-13-8996;Salongo;Sgd 301-76

Chemical Property of Oxiconazole

Chemical Property:

• Vapor Pressure: 1.06E-12mmHg at 25°C
• Refractive Index: 1.635
• Boiling Point: 576.8 °C at 760 mmHg
• PKA: 6.14±0.12(Predicted)
• Flash Point: 302.6 °C
• PSA: 39.41000
• Density: 1.42 g/cm³
• LogP: 6.11780
• Storage Temp.: 2-8°C
• XLogP3: 6.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 428.978323
• Heavy Atom Count: 26
• Complexity: 481

Purity/Quality:

99% ^*data from raw suppliers

Oxiconazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
• Isomeric SMILES: C1=CC(=C(C=C1Cl)Cl)CO/N=C(\CN2C=CN=C2)/C3=C(C=C(C=C3)Cl)Cl
• Recent NIPH Clinical Trials: Treatment of the genetic defect of cholesterol biosynthetic pathway.
• Description: Oxiconazole is a substituted imidazole derivative,it is structurally distinct from miconazole, econazole, clotrimazole, and ketoconazole because it is an acetophene-oxime derivative. It has a broad spectrum of antifungal activity including activity against yeasts, dermatophytes, and Aspergillus species.
• Uses: Oxiconazole is used as an antifungal agent. Antifungal. Oxiconazole (Oxistat) is a synthetic imidazole that works, in part, by inhibiting ergosterol 2,3-epoxidase synthesis and thereby disrupting cell membrane integrity.
• Indications: Oxiconazole (Oxistat) is a synthetic imidazole that works, in part, by inhibiting ergosterol 2,3-epoxidase synthesis and thereby disrupting cell membrane integrity.

Technology Process of Oxiconazole

There total 2 articles about Oxiconazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Dichlorobenzyl chloride (94-99-5) + (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone oxime (64211-06-9) → oxiconazole (64211-45-6)

Guidance literature:

With potassium hydroxide; In acetonitrile; at 35 ℃; for 2.5h;

Reference yield:

→ oxiconazole (76472-50-9,64211-45-6)

Guidance literature:

upstream raw materials:

2,4-Dichlorobenzyl chloride

(Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone oxime

Refernces

• 1、 -. "Imidazolyl-oxime ethers having anti-mycotic and bactericidal activity". . . Retrieved 2008/06/13.