(-)-Manthine

Base Information

• Chemical Name: (-)-Manthine
• CAS No.: 606-51-9
• Molecular Formula: C18H21NO4
• Molecular Weight: 315.36
• Mol file: 606-51-9.mol

Synonyms:

Chemical Property of (-)-Manthine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-Manthine

There total 19 articles about (-)-Manthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Isohaemanthamin (574-05-0) + methyl iodide (74-88-4) → (-)-manthine (606-51-9,109667-30-3,109667-31-4,109784-16-9,144609-74-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1021/jo801089y

Reference yield: 65.0%

haemanthamine (466-75-1) + methanol (67-56-1) → (-)-manthine (606-51-9,109667-30-3,109667-31-4,109784-16-9,144609-74-5)

Guidance literature:

haemanthamine; With methanesulfonyl chloride; In pyridine; at 0 ℃; for 8h;

methanol; With sodium hydride; In pyridine;

DOI:10.1016/j.bmcl.2018.01.041

Reference yield:

Isohaemanthamin (574-05-0) → O-Methyl-coccinin (606-51-9,109667-30-3,109667-31-4,109784-16-9,144609-74-5)

Guidance literature:

Multi-step reaction with 3 steps

1: MnO₂ / CHCl₃

2: NaBH₄ / methanol

3: (i) K, benzene, (ii) /BRN= 609209/

With manganese(IV) oxide; sodium tetrahydroborate; In methanol; chloroform;

DOI:10.1021/jo01082a019

upstream raw materials:

(-)-montanine

methanesulfonyl chloride

haemanthamine

haemanthamine

Refernces

• 1、 Hong, An-Wei,Cheng, Tsung-Hui,Raghukumar, Vellingiri,Sha, Chin-Kang. "An expedient route to montanine-type amaryllidaceae alkaloids: Total syntheses of (-)-brunsvigine and (-)-manthine". . p. 7580 - 7585. Retrieved 2008/12/22.