(E)-but-2-enehydrazide

Base Information

• Chemical Name: (E)-but-2-enehydrazide
• CAS No.: 3619-19-0
• Molecular Formula: C4H8N2O
• Molecular Weight: 100.12
• NSC Number: 11792,646
• UNII: H9PRV37HH9
• Mol file: 3619-19-0.mol

Synonyms:(E)-but-2-enehydrazide;Crotonic acid, hydrazide;NSC-646;2-BUTENOIC ACID, HYDRAZIDE;3619-19-0;H9PRV37HH9;NSC-11792;(2E)-2-Butenoic acid hydrazide;2-Butenoic acid, hydrazide, (E)-;2-Butenoic acid, hydrazide, (2E)-;UNII-H9PRV37HH9;NSC646;Crotonsaurehydrazid;62607-62-9;SCHEMBL7615061;SCHEMBL10702731;NSC11792

Chemical Property of (E)-but-2-enehydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 55.12000
• Density: 1.023g/cm³
• LogP: 0.64360
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 100.063662883
• Heavy Atom Count: 7
• Complexity: 87.7

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC=CC(=O)NN
• Isomeric SMILES: C/C=C/C(=O)NN

Technology Process of (E)-but-2-enehydrazide

There total 3 articles about (E)-but-2-enehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl crotonate (10544-63-5) → crotonyl hydrazide (3619-19-0,62607-62-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.1016/j.ejmech.2010.03.002

Reference yield:

chloroformic acid ethyl ester (541-41-3) → (E)-2-butenehydrazide (3619-19-0)

Guidance literature:

With pyridine; chloroform; und Behandeln des Reaktionsprodukts mit Hydrazin-hydrat;

DOI:10.1246/bcsj.41.2521

Reference yield:

→ crotonyl hydrazide (3619-19-0,62607-62-9)

Guidance literature:

α-Crotonsaeure, Hydrazinhydrat, 1-Butanol, akt. Al2O3, sd. Bzl. (9h);

upstream raw materials:

chloroformic acid ethyl ester

ethyl crotonate

Downstream raw materials:

butyric acid hydrazide

Refernces

• 1、 Kumar, Davinder,Judge, Vikramjeet,Narang, Rakesh,Sangwan, Sonia,De Clercq, Erik,Balzarini, Jan,Narasimhan, Balasubramanian. "Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation". experimental part. p. 2806 - 2816. Retrieved 2010/08/20.