3-BROMOIMIDAZO[1,2-A]PYRIDINE

Base Information

• Chemical Name: 3-BROMOIMIDAZO[1,2-A]PYRIDINE
• CAS No.: 4926-47-0
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2933990090
• Mol file: 4926-47-0.mol

Synonyms:3-Bromoimidazo[1,2-a]pyridine;NSC 305197;

Chemical Property of 3-BROMOIMIDAZO[1,2-A]PYRIDINE

Chemical Property:

• Melting Point: 92 °C
• Refractive Index: 1.688
• PKA: 3.85±0.50(Predicted)
• PSA: 17.30000
• Density: 1.69 g/cm³
• LogP: 2.09680
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Bromoimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): TXi
• Hazard Codes: T,Xi,Xn
• Statements: 20/21/22-22
• Safety Statements: 22-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-BROMOIMIDAZO[1,2-A]PYRIDINE

There total 3 articles about 3-BROMOIMIDAZO[1,2-A]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

imidazo[1,2-a]pyridine (274-76-0) → 3-bromoimidazo[1,2-a]pyridine (4926-47-0)

Guidance literature:

With N-Bromosuccinimide; In chloroform;

DOI:10.1016/j.bmcl.2008.04.039

Reference yield:

2-aminopyridine (504-29-0) → 3-bromoimidazo[1,2-a]pyridine (4926-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; boron trifluoride diethyl etherate / N,N-dimethyl-formamide / 24 h / 60 °C

2: dipotassium peroxodisulfate; sodium bromide / dichloromethane / 24 h / 20 °C / Sealed tube

With dipotassium peroxodisulfate; copper(l) iodide; boron trifluoride diethyl etherate; sodium bromide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.joc.8b02637

Reference yield:

→ 3-bromoimidazo[1,2-a]pyridine (4926-47-0)

Guidance literature:

Imidazo<1,2-a>pyridin I, Br2-Wasser, wss. NaOH;

upstream raw materials:

imidazo[1,2-a]pyridine

2-aminopyridine

Downstream raw materials:

C₁₂H₈BrN₃

imidazo<1,2-a>pyridin-3-acetic acid

Refernces

• 1、 Zhou, Zhilin,Yuan, Yong,Cao, Yangmin,Qiao, Jin,Yao, Anjin,Zhao, Jing,Zuo, Wanqing,Chen, Wenjie,Lei, Aiwen. "Synergy of Anodic Oxidation and Cathodic Reduction Leads to Electrochemical C—H Halogenation". supporting information. p. 611 - 615. Retrieved 2019/05/10.
• 2、 Song, Song,Sun, Xiang,Li, Xinwei,Yuan, Yizhi,Jiao, Ning. "Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization". supporting information. p. 2886 - 2889. Retrieved 2015/06/30.