{2-[(Dimethylamino)methyl]phenyl}methanol

Base Information

• Chemical Name: {2-[(Dimethylamino)methyl]phenyl}methanol
• CAS No.: 63321-79-9
• Molecular Formula: C10H15NO
• Molecular Weight: 165.235
• NSC Number: 175168
• DSSTox Substance ID: DTXSID80306294
• Wikidata: Q82053324
• Mol file: 63321-79-9.mol

Synonyms:{2-[(dimethylamino)methyl]phenyl}methanol;63321-79-9;[2-[(dimethylamino)methyl]phenyl]methanol;(2-((Dimethylamino)methyl)phenyl)methanol;NSC175168;SCHEMBL8680690;DTXSID80306294;AKOS000320951;NSC-175168;CS-0251161;EN300-53811;Z336081038

Chemical Property of {2-[(Dimethylamino)methyl]phenyl}methanol

Chemical Property:

• Vapor Pressure: 0.0158mmHg at 25°C
• Boiling Point: 244.9°Cat760mmHg
• Flash Point: 82.1°C
• PSA: 23.47000
• Density: 1.033g/cm³
• LogP: 1.24050
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 125

Purity/Quality:

99% ^*data from raw suppliers

{2-[(dimethylamino)methyl]phenyl}methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC1=CC=CC=C1CO

Technology Process of {2-[(Dimethylamino)methyl]phenyl}methanol

There total 6 articles about {2-[(Dimethylamino)methyl]phenyl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

o-N,N-dimethylaminomethylbenzoic acid (55741-01-0) → o-(N,N-dimethylaminomethyl)benzyl alcohol (63321-79-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 72h; Heating;

Reference yield: 70.0%

ethyl 2-((dimethylamino)methyl)benzoate (28276-79-1) → o-(N,N-dimethylaminomethyl)benzyl alcohol (63321-79-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Heating;

Reference yield:

2-(dimethylaminocarbonyl)benzoic acid (20320-37-0) → o-(N,N-dimethylaminomethyl)benzyl alcohol (63321-79-9)

Guidance literature:

With sodium borohydrid; oxalic acid; trifluoroborane diethyl ether; In tetrahydrofuran; methanol; water;

upstream raw materials:

o-N,N-dimethylaminomethylbenzoic acid

ethyl 2-((dimethylamino)methyl)benzoate

o-(N,N-dimethylaminomethyl)benzyl acetate

2-(dimethylaminocarbonyl)benzoic acid

Downstream raw materials:

o-(N,N-dimethylaminomethyl)benzyl acetate

1-[2-(2-Dimethylaminomethyl-benzylsulfanyl)-ethyl]-3-methyl-thiourea

2-acetoxymethyl-N,N,N-trimethylbenzenemethanaminium iodide

N-<2-(4-benzyloxy-3-methoxyphenyl)-ethyl>-(2-hydroxymethyl)phenylacetamide

Refernces

• 1、 Gaion,Grion,Montanari,Valenti,Da Re. "Modulation of cholinergic profile of acetylcholine through its cyclovinylogues". . p. 1371 - 1380. Retrieved 2007/10/02.
• 2、 Khan, Mohammad Niyaz. "Evidence for the Formation and Decay of o-(N,N-Dimethylaminomethyl)benzyl Acetate in the Reaction of p-Nitrophenyl Acetate with o-(N,N-Dimethylaminomethyl)benzyl Alcohol". . p. 2384 - 2394. Retrieved 2007/10/02.