2,4-Dichlorobenzenesulfonyl chloride

Base Information

• Chemical Name: 2,4-Dichlorobenzenesulfonyl chloride
• CAS No.: 16271-33-3
• Molecular Formula: C6H3Cl3O2S
• Molecular Weight: 245.514
• Hs Code.: 29049090
• European Community (EC) Number: 628-025-8
• DSSTox Substance ID: DTXSID40167444
• Nikkaji Number: J41.351H
• Wikidata: Q72465495
• Mol file: 16271-33-3.mol

Synonyms:2,4-Dichlorobenzenesulfonyl chloride;16271-33-3;2,4-Dichlorobenzene-1-Sulfonyl Chloride;Benzenesulfonyl chloride, 2,4-dichloro-;2,4-dichloro-benzenesulfonyl chloride;2,4-dichlorobenzenesulphonyl chloride;2,4-Dichlorobenzenesulfonylchloride;BRN 2806192;2,4-dichlorophenylsulfonyl chloride;2,4-Dichlorobenzenesulphonylchloride;4-11-00-00132 (Beilstein Handbook Reference);SCHEMBL444929;DTXSID40167444;2,4dichlorobenzenesulfonyl chloride;2,4-dichlorobenzenesufonyl chloride;2,4-dicloro benzenesulfonylchloride;2,4 dichlorobenzenesulfonyl chloride;2,4-dichloro benzenesulfonylchloride;2,4-dichlorophenylsulphonyl chloride;BBL018085;MFCD00052712;STK897843;2,4 dichloro benzenesulfonyl chloride;2,4 Dichloro-benzenesulfonyl chloride;2,4-dichlorobenzene sulfonyl chloride;AKOS002678447;2,4-dichloro benzene sulfonyl chloride;AM62506;CS-W014125;LS-32138;2,4-Dichlorobenzenesulfonyl chloride, 97%;A3620;D4037;FT-0610043;EN300-182514;J-009968;Z401601344

Chemical Property of 2,4-Dichlorobenzenesulfonyl chloride

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 0.00124mmHg at 25°C
• Melting Point: 55-58 °C(lit.)
• Refractive Index: 1.581
• Boiling Point: 308.4 °C at 760 mmHg
• Flash Point: 140.3 °C
• PSA: 42.52000
• Density: 1.636 g/cm³
• LogP: 4.00170
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Moisture Sensitive
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 243.891934
• Heavy Atom Count: 12
• Complexity: 246

Purity/Quality:

≥95% ^*data from raw suppliers

2,4-Dichlorobenzenesulfonyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)S(=O)(=O)Cl
• Uses: 2,4-Dichlorobenzenesulfonyl chloride may be used in the preparation of 2,4-dichlorothiophenol.

Technology Process of 2,4-Dichlorobenzenesulfonyl chloride

There total 7 articles about 2,4-Dichlorobenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,4-Dichloroaniline (554-00-7,51908-09-9) → 2,4-Dichlorobenzenesulfonyl chloride (16271-33-3)

Guidance literature:

2,4-Dichloroaniline; With acetic acid; for 0.166667h;

With hydrogenchloride; In water; for 0.333333h; Further stages;

Reference yield: 62.0%

1,3-Dichlorobenzene (541-73-1) → 2,4-Dichlorobenzenesulfonyl chloride (16271-33-3)

Guidance literature:

With sulfuryl dichloride; sulfuric acid; In N,N-dimethyl-formamide; at 100 ℃; for 2.5h;

DOI:10.1016/S0022-1139(99)00195-5

Reference yield:

→ 2,4-Dichlorobenzenesulfonyl chloride (16271-33-3)

Guidance literature:

With phosphorus pentachloride;

upstream raw materials:

2,4-dichloro-benzenesulfonic acid

1,3-Dichlorobenzene

chlorosulfonic acid

chloroform

Downstream raw materials:

2,4-dichlorobenzenesulfonanilide

4-benzenesulfonyl-resorcinol

2,4-dichloro-N-[2-chloro-4-(tetrahydro-pyran-2-yloxy)-benzyl]-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-benzenesulfonamide

2,4-dichloro-N-[3,5-dichloro-4-(quinolin-3-yloxy)phenyl]-benzenesulfonamide hydrochloride

Refernces

• 1、 -. "Substituted Disulfonamide Compounds". Page/Page column 44. . Retrieved 2010/06/22.
• 2、 -. "Compounds for the modulation of PPARgamma activity". . . Retrieved 2008/06/13.