2-METHYL-QUINOLINE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-METHYL-QUINOLINE-4-CARBOXYLIC ACID
• CAS No.: 634-38-8
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Hs Code.: 2933499090
• Mol file: 634-38-8.mol

Synonyms:Cinchoninicacid, 2-methyl- (6CI,7CI,8CI);2-Methyl-4-quinolinecarboxylic acid;2-Methylcinchoninic acid;4-Carboxy-2-methylquinoline;4-Quinaldinecarboxylicacid;Aniluvitonic acid;2-Methylquinoline-4-carboxylic acid;

Chemical Property of 2-METHYL-QUINOLINE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 2.5E-05mmHg at 25°C
• Melting Point: 245-247 °C
• Refractive Index: 1.663
• Boiling Point: 344.5 °C at 760 mmHg
• PKA: 1.15±0.10(Predicted)
• Flash Point: 162.2 °C
• PSA: 50.19000
• Density: 1.285 g/cm³
• LogP: 2.24140
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Methylquinoline-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methylquinoline-4-carboxylic Acid is used in preparation of dihydro pyrano pyrazol one derivatives as antitumor agents.

Technology Process of 2-METHYL-QUINOLINE-4-CARBOXYLIC ACID

There total 15 articles about 2-METHYL-QUINOLINE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + acetone (67-64-1) → 2-methylquinoline-4-carboxylic acid (634-38-8)

Guidance literature:

indole-2,3-dione; With potassium hydroxide; In water; at 20 ℃;

acetone; In water; Heating;

DOI:10.1023/B:RUJO.0000019750.72414.48

Reference yield: 91.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + 2-methylquinolin-4-yl 2,3,4,5,6-pentafluorobenzenesulfonate → 2-methylquinoline-4-carboxylic acid (634-38-8)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; water; at 20 ℃; for 16h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201600736

Reference yield: 90.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + 2-methylquinolin-4-yl trifluoromethanesulfonate (123172-90-7) → 2-methylquinoline-4-carboxylic acid (634-38-8)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; water; at 20 ℃; for 16h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201600736

upstream raw materials:

2,4-dimethylquinoline

2-methylquinoline-4-carboxamide

indole-2,3-dione

acetaldehyde

Downstream raw materials:

methyl 2-methylquinoline-4-carboxylate

2-methylquinoline

4-hydroxy-2-methylquinoline

2-methylquinoline-4-carboxamide

Refernces

• 1、 Abdelwahid, Mazin A. S.,Elsaman, Tilal,Mohamed, Malik S.,Latif, Sara A.,Mukhtar, Moawia M.,Mohamed, Magdi A.. "Synthesis, characterization, and antileishmanial activity of certain quinoline-4-carboxylic acids". . . Retrieved 2019/03/08.
• 2、 Li, Wenlong,Xu, Feijie,Shuai, Wen,Sun, Honghao,Yao, Hong,Ma, Cong,Xu, Shengtao,Yao, Hequan,Zhu, Zheying,Yang, Dong-Hua,Chen, Zhe-Sheng,Xu, Jinyi. "Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity". . p. 993 - 1013. Retrieved 2019/01/11.