MESO-2 3-DIAMINOSUCCINIC ACID

Base Information

• Chemical Name: MESO-2 3-DIAMINOSUCCINIC ACID
• CAS No.: 23220-52-2
• Molecular Formula: C4H8N2O4
• Molecular Weight: 148.119
• Hs Code.: 2922499990
• European Community (EC) Number: 245-500-1
• DSSTox Substance ID: DTXSID701307806
• Nikkaji Number: J318.428E
• Wikidata: Q76006132
• Mol file: 23220-52-2.mol

Synonyms:Asparticacid, 3-amino-, erythro-;Succinic acid, 2,3-diamino-, meso- (8CI);meso-2,3-Diaminosuccinic acid;meso-Diaminosuccinic acid;

Chemical Property of MESO-2 3-DIAMINOSUCCINIC ACID

Chemical Property:

• Vapor Pressure: 0.000197mmHg at 25°C
• Melting Point: 304 °C
• Refractive Index: 1.582
• Boiling Point: 304.7 °C at 760 mmHg
• PKA: 1.43±0.27(Predicted)
• Flash Point: 138.1 °C
• PSA: 126.64000
• Density: 1.611 g/cm³
• LogP: -0.78920
• XLogP3: -7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 148.04840674
• Heavy Atom Count: 10
• Complexity: 139

Purity/Quality:

98%,99%, ^*data from raw suppliers

meso-2,3-Diaminosuccinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C(C(=O)O)N)(C(=O)O)N
• Isomeric SMILES: [C@@H]([C@@H](C(=O)O)N)(C(=O)O)N
• Uses: meso-2,3-Diaminosuccinic Acid is used as a building block in organic synthesis. As well as used in the synthesis of metal complexes for antitumor activity.

Technology Process of MESO-2 3-DIAMINOSUCCINIC ACID

There total 21 articles about MESO-2 3-DIAMINOSUCCINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,3S)-2,3-bis(benzylamino)succinic acid (55645-40-4) → (2S,3R)-3-aminoaspartic acid (23220-52-2)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In water; acetic acid; at 50 ℃; for 48h;

Reference yield: 75.0%

8-phenylmenthyl 3-amino-N,N'-bis[bis(methylthio)methylene]aspartate → (2S,3S)-3-aminoaspartic acid (38484-81-0) + (2S,3R)-3-aminoaspartic acid (23220-52-2)

Guidance literature:

With hydrogenchloride; In water; trifluoroacetic acid; for 18h; Heating;

DOI:10.1021/jo962116c

Reference yield:

racem-2,3-bis-benzylamino-succinic acid (53079-45-1,55645-40-4) → (2S,3R)-3-aminoaspartic acid (23220-52-2)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; water; durch Hydrogenolyse;

DOI:10.1021/jo01159a004

upstream raw materials:

(2R,3S)-2,3-bis(benzylamino)succinic acid

racem-2,3-bis-benzylamino-succinic acid

2,2-Dibromo-succinic acid

2,3-Diformamino-2,3-diaethoxycarbonyl-bernsteinsaeure-diaethylester

Downstream raw materials:

DL-tartaric acid

tartaric acid

meso-2,3-dibromosuccinic acid

2,3-dibromosuccinic acid

Refernces

• 1、 Wenner. "-". . p. 26,28,29. Retrieved 1948.
• 2、 -. "CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP". Page/Page column 308. . Retrieved 2020/05/19.
• 3、 Liao, Jen-Hai,Cheng, Kuang-Yuan,Fang, Jim-Min,Cheng, Ming-Chu,Wang, Yu. "Oxidation of Alkenes and Sulfides with Transition Metal Catalysts". . p. 847 - 860. Retrieved 2007/10/03.