N~5~-(diaminomethylidene)-N~2~-[(4-methylphenyl)sulfonyl]-L-ornithylglycine

Base Information

• Chemical Name: N~5~-(diaminomethylidene)-N~2~-[(4-methylphenyl)sulfonyl]-L-ornithylglycine
• CAS No.: 857-07-8
• Molecular Formula: C₁₅H₂₃N₅O₅S
• Molecular Weight: 385.444
• Mol file: 857-07-8.mol

Synonyms:

Chemical Property of N~5~-(diaminomethylidene)-N~2~-[(4-methylphenyl)sulfonyl]-L-ornithylglycine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.45g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N~5~-(diaminomethylidene)-N~2~-[(4-methylphenyl)sulfonyl]-L-ornithylglycine

There total 8 articles about N~5~-(diaminomethylidene)-N~2~-[(4-methylphenyl)sulfonyl]-L-ornithylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H28N6O7S → N-[Nα-(toluene-4-sulfonyl)-L-arginyl]-glycine (857-07-8)

Guidance literature:

With hydrogen; palladium; In water; acetic acid; butan-1-ol;

Reference yield:

Nα-tosyl-NG-nitro-L-arginine (51786-02-8) → N-[Nα-(toluene-4-sulfonyl)-L-arginyl]-glycine (857-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) ethylchloroformate, 2.) Et₃N / 1.) DMF, 2.) DMF

2: H₂ / palladium black / butan-1-ol; acetic acid; H₂O

With hydrogen; chloroformic acid ethyl ester; triethylamine; palladium; In water; acetic acid; butan-1-ol;

Reference yield:

GlyOEt*HCl (459-73-4) → N-[Nα-(toluene-4-sulfonyl)-L-arginyl]-glycine (857-07-8)

Guidance literature:

With diphosphorous acid tetraethyl ester; phosphonic acid diethyl ester;

DOI:10.1039/jr9570003134

upstream raw materials:

GlyOEt*HCl

N^α-tosyl-N^G-nitro-L-arginine

N-carboxybenzyl-L-ornithine

N⁵-benzyloxycarbonyl-N²-(toluene-4-sulfonyl)-L-ornithine

Refernces