2-METHOXYPHENYLACETYL CHLORIDE

Base Information

• Chemical Name: 2-METHOXYPHENYLACETYL CHLORIDE
• CAS No.: 28033-63-8
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Hs Code.: 2918990090
• Mol file: 28033-63-8.mol

Synonyms:2-(2-Methoxyphenyl)acetyl chloride;Benzeneacetyl chloride, 2-methoxy-;

Chemical Property of 2-METHOXYPHENYLACETYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.0163mmHg at 25°C
• Refractive Index: 1.524
• Boiling Point: 255.4 °C at 760 mmHg
• Flash Point: 95.1 °C
• PSA: 26.30000
• Density: 1.192 g/cm³
• LogP: 2.00310

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-methoxyphenyl)acetylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXYPHENYLACETYL CHLORIDE

There total 8 articles about 2-METHOXYPHENYLACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxyphenylacetic acid (93-25-4) → 2-(2-methoxyphenyl)acetyl chloride (28033-63-8)

Guidance literature:

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.6b01771

Reference yield:

oxalyl dichloride (79-37-8) + 2-methoxyphenylacetic acid (93-25-4) → 2-(2-methoxyphenyl)acetyl chloride (28033-63-8)

Guidance literature:

In dichloromethane;

Reference yield:

2-hydroxy-2-(2-methoxyphenyl)acetonitrile (121985-99-7,53313-93-2) → 2-(2-methoxyphenyl)acetyl chloride (28033-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / SnCl₂, HI, HCl / acetic acid

2: SOCl₂ / benzene / Heating

With hydrogenchloride; thionyl chloride; hydrogen iodide; tin(ll) chloride; In acetic acid; benzene;

DOI:10.1016/0040-4020(89)80142-5

upstream raw materials:

2-methoxyphenylacetic acid

2-hydroxy-2-(2-methoxyphenyl)acetonitrile

salicylaldehyde

ortho-anisaldehyde

Downstream raw materials:

2-(2-methoxyphenyl)-1-(4-methoxyphenyl)ethan-1-one

[(2-methoxy-phenyl)-acetyl]-malonic acid diethyl ester

N,N-Di-sec-butyl-2-(2-methoxy-phenyl)-acetamide

6β-[2-(2-methoxy-phenyl)-acetylamino]-penicillanic acid

Refernces

• 1、 Fang, Hai-Lian,He, Jie-Ling,Li, Wei-Yi,Liu, Shan-Shan,Ni, Wei-Wei,Pan, Xing-Ming,Xiao, Zhu-Ping,Ye, Ya-Xi,Yi, Juan,Zhou, Mi,Zhou, Tian-Li,Zhu, Hai-Liang. "N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation". . p. 404 - 413. Retrieved 2020/01/03.
• 2、 Gu, Linghui,He, Meicui,Ma, Wenbo,Tan, Yuqiang,Wang, Yang,Wang, Yuchi,Zhang, Chunran. "Palladium-Catalyzed Distal C?H Selenylation of 2-Aryl Acetamides with Diselenides and Selenyl Chlorides". supporting information. p. 5708 - 5715. Retrieved 2020/12/01.