2-[2-(2-Methoxyethoxy)ethoxy]ethylamine

Base Information

• Chemical Name: 2-[2-(2-Methoxyethoxy)ethoxy]ethylamine
• CAS No.: 74654-07-2
• Molecular Formula: C7H17 N O3
• Molecular Weight: 163.217
• Hs Code.: 2922199090
• European Community (EC) Number: 277-952-0
• DSSTox Substance ID: DTXSID30996169
• Nikkaji Number: J349.443H
• Mol file: 74654-07-2.mol

Synonyms:74654-07-2;2-(2-(2-Methoxyethoxy)ethoxy)ethanamine;m-PEG3-Amine;2-[2-(2-Methoxyethoxy)ethoxy]ethylamine;mPEG3-NH2;2-[2-(2-methoxyethoxy)ethoxy]ethanamine;2-{2-(2-methoxyethoxy)ethoxy}ethylamine;EINECS 277-952-0;MFCD17215909;2-(2-(2-methoxyethoxy)ethoxy)ethan-1-amine;1-[2-(2-AMINOETHOXY)ETHOXY]-2-METHOXYETHANE;2-(2-(2-Methoxyethoxy)ethoxy)ethylamine;Ethanamine, 2-[2-(2-methoxyethoxy)ethoxy]-;2-[2-(2-Methoxyethoxy)ethoxy]ethan-1-amine;Methyl-PEG3-amine;SCHEMBL942035;3,6,9-Trioxadecane-1-amine;YSSJ00972;DTXSID30996169;OKUWOEKJQRUMBW-UHFFFAOYSA-N;BCP11313;AKOS013509846;CS-W018960;GS-6416;HY-W018174;BP-20975;SY112854;2-(2-(2-methoxyethoxy)-ethoxy)ethanamine;2-(2-(2-Methoxyethoxy)ethoxy)-ethanamine;2-(2-(2-methoxyethoxy)ethoxy)ethyl amine;2-(2-(2-methoxyethoxyl)ethoxy)ethanamine;2-(2-(2-methoxyethoxyl)ethoxy)-ethanamine;FT-0701206;2-[2-(2-methoxy-ethoxy)-ethoxy]-ethylamine;EN300-761802;J-507632

Chemical Property of 2-[2-(2-Methoxyethoxy)ethoxy]ethylamine

Chemical Property:

• Vapor Pressure: 0.0939mmHg at 25°C
• Refractive Index: 1.4395 (589.3 nm 20℃)
• Boiling Point: 106℃ (11 Torr)
• PKA: 8.74±0.10(Predicted)
• Flash Point: 86.1°C
• PSA: 53.71000
• Density: 0.978g/cm³
• LogP: 0.32500
• Storage Temp.: 2-8°C
• Solubility.: Soluble in Water, DMSO, DCM, DMF
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 163.12084340
• Heavy Atom Count: 11
• Complexity: 70.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-(2-Methoxyethoxy)ethoxy)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCCOCCN
• Description: m-PEG3-amine is a PEG reagent containing an amino group (NH2). The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.
• Uses: m-PEG3-amine whose chemical name 2-[2-(2-methoxyethoxy)ethoxy]ethylamine,it is a PROTAC bridge, belonging to the PEG class, which can be used to synthesize a series of PROTAC molecules, and can also be used for the synthesis of antibody drug conjugates (ADCs).

Technology Process of 2-[2-(2-Methoxyethoxy)ethoxy]ethylamine

There total 10 articles about 2-[2-(2-Methoxyethoxy)ethoxy]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-(2-methoxyethoxy)ethoxy)ethyl azide (74654-06-1,89485-61-0) → 2-[2-(2-methoxyethoxy)ethoxy]ethylamine (74654-07-2,80506-64-5,869718-87-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 86.0%

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3) → 2-[2-(2-methoxyethoxy)ethoxy]ethylamine (74654-07-2,80506-64-5,869718-87-6)

Guidance literature:

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate; With potassium phtalimide; In N,N-dimethyl-formamide; at 120 ℃; for 4h;

With hydrazine hydrate; In ethanol; for 6h; Reflux;

Reference yield: 84.0%

N-[2-(2-(2-methoxyethoxy)ethoxy)ethyl]phthalimide (167221-50-3) → 2-[2-(2-methoxyethoxy)ethoxy]ethylamine (74654-07-2,80506-64-5,869718-87-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Reflux;

DOI:10.1016/j.molstruc.2011.01.025

upstream raw materials:

1-chloro-3,6,9-trioxadecane

2-(2-(2-methoxyethoxy)ethoxy)ethyl azide

N-[2-(2-(2-methoxyethoxy)ethoxy)ethyl]phthalimide

triethylene glucol monomethyl ether

Downstream raw materials:

tris-(3,6,9-trioxadecyl)-amine

(SP-4-2)-([tetrakis[2-[2-(2-methoxyethoxy)ethoxy]ethyl] 4,4',4'',4'''-[10-(3,5-bis[[6-(1H-imidazol-1-yl)hexyl]oxy]-4-methylphenyl)-21H,23H-porphine-1,15-diylbis(benzene-2,1,3-triyldioxy)]tetrakis[butanamido]]^(2-)-N⁽²¹⁾,N⁽²²⁾,N⁽²³⁾,N⁽²⁴⁾)zinc(II)

Refernces

• 1、 Dombi, Kendra L.,Griesang, Niels,Richert, Clemens. "Oligonucleotide arrays from aldehyde-bearing glass with coated background". . p. 816 - 824. Retrieved 2002.
• 2、 -. "MULTI-ELECTRON REDOX-ACTIVE ORGANIC MOLECULES FOR HIGH-ENERGY-DENSITY NONAQUEOUS REDOX FLOW BATTERIES". . . Retrieved 2020/12/11.
• 3、 Borissov, Arseni,Marques, Igor,Lim, Jason Y.C.,Félix, Vítor,Smith, Martin D.,Beer, Paul D.. "Anion Recognition in Water by Charge-Neutral Halogen and Chalcogen Bonding Foldamer Receptors". supporting information. p. 4119 - 4129. Retrieved 2019/03/07.