1-BENZOFURAN-6-OL

Base Information

• Chemical Name: 1-BENZOFURAN-6-OL
• CAS No.: 13196-11-7
• Molecular Formula: C8H6O2
• Molecular Weight: 134.134
• Hs Code.: 2932999099
• Mol file: 13196-11-7.mol

Synonyms:6-Hydroxybenzo[b]furan;6-Hydroxybenzofuran;

Chemical Property of 1-BENZOFURAN-6-OL

Chemical Property:

• Vapor Pressure: 20mmHg at 25°C
• Melting Point: 108℃
• Refractive Index: 1.651
• Boiling Point: 110.7 °C at 760 mmHg
• PKA: 9.20±0.40(Predicted)
• Flash Point: 20.7 °C
• PSA: 33.37000
• Density: 1.28 g/cm³
• LogP: 2.13840
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Benzofuran-6-Ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZOFURAN-6-OL

There total 34 articles about 1-BENZOFURAN-6-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-(tert-butyl-dimethylsilanyloxy)-[2H]-benzofuran-3-one (299912-77-9) → 6-hydroxybenzofuran (13196-11-7)

Guidance literature:

6-(tert-butyl-dimethylsilanyloxy)-[2H]-benzofuran-3-one; With sodium tetrahydroborate; In methanol; at 20 ℃;

In acetone; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; Darkness; Inert atmosphere;

DOI:10.1021/ml2002482

Reference yield: 90.0%

6-methoxybenzofuran (50551-63-8) → 6-hydroxybenzofuran (13196-11-7)

Guidance literature:

With sodium dodecanethiolate; In N,N-dimethyl-formamide; at 130 ℃; for 3h; Temperature; Reagent/catalyst; Large scale;

DOI:10.1007/s11164-015-2288-7

Reference yield: 78.0%

4-(2-Nitroethyl)benzene-1,3-diol (96853-42-8) → 6-hydroxybenzofuran (13196-11-7)

Guidance literature:

4-(2-Nitroethyl)benzene-1,3-diol; With sodium methylate; silica gel; at 20 ℃; for 24h;

With hydrogenchloride; at 20 ℃; for 0.5h;

DOI:10.1055/s-2006-926250

upstream raw materials:

6-hydroxy-benzofuran-3-one oxime

6-hydroxybenzofuran-2-carboxylic acid

1-benzofurane

6-methoxybenzofuran

Downstream raw materials:

6-[2-(Difluoromethoxy)-4-(trifluoromethyl)phenoxy]-1-benzofuran

6-[(3-iodobenzyl)oxy]-1-benzofuran

6-[2-chloro-4-(trifluoromethyl)phenoxy]-1-benzofuran

C₁₄H₉IO₂

Refernces

• 1、 Cao, Jun,Chen, Zi-Li,Li, Shu-Min,Zhu, Gao-Feng,Yang, Yuan-Yong,Wang, Cong,Chen, Wen-Zhang,Wang, Jian-Ta,Zhang, Ji-Quan,Tang, Lei. "Palladium-Catalyzed Regioselective C-2 Arylation of Benzofurans with N′-Acyl Arylhydrazines". . p. 2774 - 2779. Retrieved 2018/06/21.
• 2、 Song, Shu-Yong,Lu, He-Lin,Wang, Gui-Fei,Yang, Yi-Qiu,Huang, Yun-Sheng. "An improved and scale-up synthesis of 6-hydroxybenzofuran". . p. 4433 - 4442. Retrieved 2016/07/06.