2,4-Dichlorobenzophenone

Base Information

• Chemical Name: 2,4-Dichlorobenzophenone
• CAS No.: 19811-05-3
• Molecular Formula: C13H8Cl2O
• Molecular Weight: 251.112
• Hs Code.: 2914700090
• European Community (EC) Number: 243-338-6
• DSSTox Substance ID: DTXSID50173531
• Nikkaji Number: J82.899H
• Wikidata: Q72465528
• Mol file: 19811-05-3.mol

Synonyms:2,4-Dichlorobenzophenone;19811-05-3;(2,4-Dichlorophenyl)(phenyl)methanone;(2,4-dichlorophenyl)-phenylmethanone;Methanone, (2,4-dichlorophenyl)phenyl-;Benzophenone, 2,4-dichloro-;EINECS 243-338-6;2,4-Dichlorobenzophendne;benzoyl-2,4-dichlorobenzene;SCHEMBL522683;2,4-Dichlorobenzophenone, 99%;DTXSID50173531;MFCD00018374;(2,4-dichlorophenyl)-phenyl-methanone;AKOS006037400;(2,4-Dichlorophenyl)(phenyl)methanone #;AS-16042;CS-0320734;D0342;FT-0637910;D89630

Chemical Property of 2,4-Dichlorobenzophenone

Chemical Property:

• Vapor Pressure: 1.5E-05mmHg at 25°C
• Melting Point: 47 °C
• Refractive Index: 1.603
• Boiling Point: 366.1 °C at 760 mmHg
• Flash Point: 154.8 °C
• PSA: 17.07000
• Density: 1.311 g/cm³
• LogP: 4.22440
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: very faint turbidity in Methanol
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 249.9952203
• Heavy Atom Count: 16
• Complexity: 248

Purity/Quality:

98% ^*data from raw suppliers

2,4-Dichlorobenzophenone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)Cl)Cl
• Uses: 2,4-Dichlorobenzophenone is a useful synthetic compound.

Technology Process of 2,4-Dichlorobenzophenone

There total 26 articles about 2,4-Dichlorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

benzoyl chloride (98-88-4) + 2,4-dichlorophenylboronic acid (68716-47-2) → 2,4-dichlorobenzophenone (19811-05-3)

Guidance literature:

With C₃₂H₂₈N₆Pd⁽²⁺⁾*2Br^(1-); potassium carbonate; In toluene; at 60 ℃; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1002/aoc.5421

Reference yield: 85.0%

(E)-2,4-dichloro-1-styrylbenzene (1657-47-2) → 2,4-dichlorobenzophenone (19811-05-3)

Guidance literature:

With sodium periodate; tetraethylammonium iodide; In water; acetonitrile; at 105 ℃; for 12h; Sealed tube;

DOI:10.1039/c4ra08764j

Reference yield: 83.0%

benzoyl triflate (36967-85-8) + 1,3-Dichlorobenzene (541-73-1) → 2,4-dichlorobenzophenone (19811-05-3)

Guidance literature:

at 100 ℃; for 24h; Glovebox;

DOI:10.1002/anie.201814660

upstream raw materials:

benzoyl chloride

1,3-Dichlorobenzene

2,4-dichlorobenzoyl chloride

benzene

Downstream raw materials:

(2,4-Dichloro-phenyl)-isothiazol-5-yl-phenyl-methanol

(2,4-dichlorophenyl)phenyl-(2-aminothiazol-5-yl)carbinol

(R)-(2,4-dichlorophenyl)(phenyl)methanol

(S)-(2,4-dichlorophenyl)(phenyl)methanol

Refernces

• 1、 Muniyappan, Nalluchamy,Sabiah, Shahulhameed. "Synthesis, structure, and characterization of picolyl- and benzyl-linked biphenyl palladium N-heterocyclic carbene complexes and their catalytic activity in acylative cross-coupling reactions". . . Retrieved 2020/01/28.
• 2、 Fu, Ying,Ma, Xian-Zhen,Shi, Chun-Zhao,Shen, Tong,Du, Zhengyin. "MeZnOMe-mediated reaction of aldehydes with Grignard reagents: A glance into nucleophilic addition/Oppenauer oxidation pathway". . . Retrieved 2018/07/31.