Z-GLY-GLY-GLY-GLY-OH

Base Information

• Chemical Name: Z-GLY-GLY-GLY-GLY-OH
• CAS No.: 7770-50-5
• Molecular Formula: C16H20 N4 O7
• Molecular Weight: 380.357
• Mol file: 7770-50-5.mol

Synonyms:Glycine,N-[N-[N-(N-carboxyglycyl)glycyl]glycyl]-, N-benzyl ester (6CI,7CI,8CI);Glycine, N-[N-[N-[N-[(phenylmethoxy)carbonyl]glycyl]glycyl]glycyl]-; NSC 402054

Chemical Property of Z-GLY-GLY-GLY-GLY-OH

Chemical Property:

• Vapor Pressure: 5.19E-32mmHg at 25°C
• Boiling Point: 866.1°Cat760mmHg
• Flash Point: 477.6°C
• PSA: 162.93000
• Density: 1.363g/cm³
• LogP: -0.09040
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Z-Gly-Gly-Gly-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-GLY-GLY-GLY-GLY-OH

There total 7 articles about Z-GLY-GLY-GLY-GLY-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

CbzGlyGly (2566-19-0) → N-benzyloxycarbonylglycylglycylglycylglycine (7770-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: different/several chlorocarbonic acid esters / anschliessend Behandeln mit Glycin

2: Edukt 4: THF; anschliessend Behandeln mit Glycin und wss. NaOH

With several chlorocarbonic acid esters;

Reference yield:

glycine-glycine-glycine (556-33-2) + N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) → N-benzyloxycarbonylglycylglycylglycylglycine (7770-50-5)

Guidance literature:

With sodium hydroxide; at 0 ℃;

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → N-benzyloxycarbonylglycylglycylglycylglycine (7770-50-5)

Guidance literature:

With 3-ethoxy-3-diethoxyphosphoryloxy-acrylic acid ethyl ester; acetone; Behandeln des Reaktionsgemisches mit N-<N-(N-Benzyloxycarbonyl-glycyl)-glycyl>-glycin und wss. NaOH;

DOI:10.1017/S0003598X00089973

upstream raw materials:

1-ethyl-piperidine

octyl chloroformate

[2-(2-Benzyloxycarbonylamino-acetylamino)-acetylamino]-acetic acid

glycine-glycine-glycine

Downstream raw materials:

glycine-glycine-glycine

N-(Benzyloxycarbonyl)glycine

N-benzyloxycarbonyl-glycyl=>glycyl=>glycyl=>glycylmercapto-acetic acid

Z-(Gly)6-OEt