(4-Acetylphenyl)urea

Base Information

• Chemical Name: (4-Acetylphenyl)urea
• CAS No.: 13143-02-7
• Molecular Formula: C9H10 N2 O2
• Molecular Weight: 178.191
• Hs Code.: 2924299090
• Mol file: 13143-02-7.mol

Synonyms:Urea,(4-acetylphenyl)- (9CI); Urea, (p-acetylphenyl)- (7CI,8CI);4-Ureidoacetophenone; NSC 27464

Chemical Property of (4-Acetylphenyl)urea

Chemical Property:

• Vapor Pressure: 0.000174mmHg at 25°C
• Boiling Point: 329.7°Cat760mmHg
• PKA: 14.29±0.50(Predicted)
• Flash Point: 153.2°C
• PSA: 72.19000
• Density: 1.261
• LogP: 2.15310

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-acetylphenyl)urea ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Acetylphenyl)urea

There total 6 articles about (4-Acetylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-acetylphenyl cyanamide (75106-15-9) → N-(4-acetylphenyl)urea (13143-02-7)

Guidance literature:

With silver; water; for 1h; Reflux;

DOI:10.1016/j.saa.2014.04.186

Reference yield:

C16H16N2O2 (893187-73-0) → N-(4-acetylphenyl)urea (13143-02-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium; In methanol; at 20 ℃; for 20h;

DOI:10.1016/j.materresbull.2014.03.038

Reference yield:

para-bromoacetophenone (99-90-1) → N-(4-acetylphenyl)urea (13143-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ; caesium carbonate / 1 h / 120 °C / Inert atmosphere; Microwave irradiation; Green chemistry

2: palladium; hydrogenchloride; hydrogen / methanol / 20 h / 20 °C

With hydrogenchloride; hydrogen; caesium carbonate; palladium; In methanol;

DOI:10.1016/j.materresbull.2014.03.038

upstream raw materials:

phenyl carbamate

acetyl chloride

potassium cyanate

4-acetylphenyl cyanamide

Downstream raw materials:

C₃₄H₃₂N₆O₈S

Refernces

• 1、 Balabon, Olga,Pitta, Eleni,Rogacki, MacIej K.,Meiler, Eugenia,Casanueva, Ruth,Guijarro, Laura,Huss, Sophie,Lopez-Roman, Eva Maria,Santos-Villarejo, ángel,Augustyns, Koen,Ballell, Lluis,Aguirre, David Barros,Bates, Robert H.,Cunningham, Fraser,Cacho, Monica,Van Der Veken, Pieter. "Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β-d-Ribose Oxidase (DprE1) Inhibitors". supporting information. p. 5367 - 5386. Retrieved 2020/06/17.
• 2、 Nasrollahzadeh, Mahmoud,Azarian, Abbas,Ehsani, Ali,Sajadi, S.Mohammad,Babaei, Ferydon. "Hybrid Pd/Fe3O4 nanowires: Fabrication, characterization, optical properties and application as magnetically reusable catalyst for the synthesis of N-monosubstituted ureas under ligand-free conditions". . p. 168 - 175. Retrieved 2014/05/20.