CARAZOSTATIN

Base Information

• Chemical Name: CARAZOSTATIN
• CAS No.: 126168-32-9
• Molecular Formula: C₂₀H₂₅NO
• Molecular Weight: 295.425
• Mol file: 126168-32-9.mol

Synonyms:1-Heptyl-2-methyl-3-hydroxycarbazole;1-Heptyl-3-hydroxy-2-methylcarbazole;Carazostatin;DC 118;1-heptyl-2-methyl-9H-carbazol-3-ol;9H-Carbazol-3-ol, 1-heptyl-2-methyl-;1-Heptyl-2-methyl-9H-carbazol-3-ol;

Chemical Property of CARAZOSTATIN

Chemical Property:

• Appearance/Colour: Pale Yellow Solid
• Vapor Pressure: 1.64E-10mmHg at 25°C
• Melting Point: 159-160 °C
• Refractive Index: 1.639
• Boiling Point: 497.3 °C at 760 mmHg
• PKA: 10.51±0.30(Predicted)
• Flash Point: 254.5 °C
• PSA: 36.02000
• Density: 1.11 g/cm³
• LogP: 5.84800
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

CARAZOSTATIN 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CARAZOSTATIN

There total 21 articles about CARAZOSTATIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-ethoxy-1-heptyl-2-methylcarbazole (176327-52-9) → 1-heptyl-3-hydroxy-2-methyl-9H-carbazole (126168-32-9)

Guidance literature:

With boron tribromide;

DOI:10.1016/0040-4039(96)00378-4

Reference yield: 87.0%

Formic acid 1-heptyl-2-methyl-9H-carbazol-3-yl ester (162975-02-2) → 1-heptyl-3-hydroxy-2-methyl-9H-carbazole (126168-32-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1246/cl.1995.289

Reference yield: 57.0%

1-(1-heptyl-3-hydroxy-2-methyl-carbazol-9-yl)-ethanone → 1-heptyl-3-hydroxy-2-methyl-9H-carbazole (126168-32-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

DOI:10.3987/COM-00-8940

upstream raw materials:

1-heptyl-2-methyl-3-trimethylsilyl-9H-carbazole

Formic acid 1-heptyl-2-methyl-9H-carbazol-3-yl ester

3-ethoxy-1-heptyl-2-methylcarbazole

2-heptyl-4-methoxy-3-methylaniline

Downstream raw materials:

5-heptyl-4-methyl-2-phenyl-6H-oxazolo<5,4-c>carbazole

1-heptyl-3-methoxy-2,9-dimethyl-9H-carbazole

1-heptyl-3-methoxy-2-methyl-9H-carbazole

3-acetoxy-1-heptyl-2-methyl-9H-carbazole

Refernces

• 1、 Kn?lker, Hans-Joachim,Hopfmann, Thomas. "Transition metal complexes in organic synthesis. Part 65: Iron-mediated synthesis of carazostatin, a free radical scavenger from Streptomyces chromofuscus, and O-methylcarazostatin". . p. 8937 - 8945. Retrieved 2007/10/03.
• 2、 Choshi, Tominari,Sada, Takuya,Fujimoto, Hiroyuki,Nagayama, Chizu,Sugino, Eiichi,Hibino, Satoshi. "Total Syntheses of Carazostatin, Hyellazule, and Carbazoquinocins B-F". . p. 2535 - 2543. Retrieved 2007/10/03.