15-hydroxybimol.cyclic ester ;;

Base Information

• Chemical Name: 15-hydroxybimol.cyclic ester
• CAS No.: 659-76-7
• Molecular Formula: C₃₀H₅₆O₄
• Molecular Weight: 480.772
• Mol file: 659-76-7.mol

Synonyms:

Chemical Property of 15-hydroxybimol.cyclic ester ;;

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 15-hydroxybimol.cyclic ester ;;

There total 10 articles about 15-hydroxybimol.cyclic ester ;; which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

15-hydroxylpentadecanoic acid (4617-33-8) → pentadecanolide (106-02-5,81031-90-5) + 1,17-dioxa-cyclodotriacontane-2,18-dione (659-76-7)

Guidance literature:

With p-nitrobenzoic anhydride; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; acetonitrile; Yields of byproduct given; Heating;

DOI:10.1021/jo952237x

Reference yield: 90.0%

Acrylic acid 12-iodo-dodecyl ester (109182-98-1) → pentadecanolide (106-02-5,81031-90-5) + 1,17-dioxa-cyclodotriacontane-2,18-dione (659-76-7)

Guidance literature:

With sodium cyanoborohydride; In methanol; for 3h; Ambient temperature; Irradiation;

DOI:10.1246/cl.1994.1789

Reference yield: 89.0%

trimethylsilyl 15-(trimethylsiloxy)pentadecanoate (93472-40-3) → pentadecanolide (106-02-5,81031-90-5) + 1,17-dioxa-cyclodotriacontane-2,18-dione (659-76-7)

Guidance literature:

With 4-(trifluoromethyl)benzoic anhydride; silver perchlorate; titanium tetrachloride; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1246/cl.1993.907

upstream raw materials:

15-hydroxylpentadecanoic acid

methyl 15-hydroxypentadecanoate

15-iodo-pentadecanoic acid

trimethylsilyl 15-(trimethylsiloxy)pentadecanoate

Refernces

• 1、 Oohashi, Yoshiaki,Fukumoto, Kentarou,Mukaiyama, Teruaki. "Efficient method for the lactonization of ω-hydroxycarboxylic acids with di-2-thienyl carbonate by the promotion of catalytic amounts of DMAP and Hf(OTf)4". . p. 710 - 711. Retrieved 2007/10/03.
• 2、 Oohashi, Yoshiaki,Fukumoto, Kentarou,Mukaiyama, Teruaki. "A new method for the lactonization of ω-hydroxy carboxylic acids with Di-2-thienyl carbonate by the promotion of DMAP and iodine". . p. 72 - 73. Retrieved 2007/10/03.